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Gibson Lab
NEWS: 
Article
June 4, 2021
Decades of Research Advancements Pave the Way to Slow Down Alzheimer’s Disease by Targeting Early-Onset
Today, scientists still do not know the cause of Alzheimer’s disease (AD), yet decades of research advancements give hope to the possibility of slowing down early-onset of AD. Benfotiamine, a therapeutic drug that raises blood vitamin B1, levels very high, was recently tested as a pilot clinical study conducted by the Gibson Lab at the Burke Neurological Institute.
Gibson Team in the Lab
Gibson Lab
NEWS: 
In the Media
December 29, 2020
Benfotiamine and Cognitive Decline in Alzheimer's Disease Study Listed as a Top Non-Pandemic Advances in Health Care During 2020
Media Outlet: 
CNN Health
Benfotiamine and Cognitive Decline in Alzheimer's Disease, a small exploratory clinical trial, conducted by Dr. Gary E. Gibson’s laboratory at the Burke Neurological Institute is listed in CNN Health’s article on ”Top 2020 health stories you may have missed because of Covid-19” under Advances in Alzheimer’s.
Gibson Team in the Lab
Gibson Lab
NEWS: 
Article
November 25, 2020
New Data Suggests Raising Vitamin B1 Levels very high Helps People Living with mild Alzheimer’s Disease
A small exploratory clinical trial conducted by Dr. Gary E. Gibson’s laboratory at the Burke Neurological Institute in collaboration with physicians at the Burke Rehabilitation Hospital, suggests that Benfotiamine is safe and potentially efficacious in improving cognitive outcomes among people living with Mild Cognitive Impairment and mild Alzheimer’s disease (AD).
Photo of Gibson Lab
Ratan Lab
PUBLICATION: 
Review
Orjon Rroji, Amit Kumar, Saravanan S Karuppagounder, Rajiv R Ratan
Epigenetic regulators of neuronal ferroptosis identify novel therapeutics for neurological diseases: HDACs, transglutaminases, and HIF prolyl hydroxylases
Neurobiol Dis . 2020 Oct 27;105145. doi: 10.1016/j.nbd.2020.105145. Online ahead of print.
Abstract on PubMed
Gibson Lab
PUBLICATION: 
Manuscript
Gary E Gibson, José A Luchsinger, Rosanna Cirio, Huanlian Chen, Jessica Franchino-Elder, Joseph A Hirsch, Lucien Bettendorff, Zhengming Chen, Sarah Flowers, Linda Gerber, Thomas Grandville, Nicole Schupf, Hui Xu, Yaakov Stern, Christian Habeck, Barry Jordan, Pasquale Fonzetti
Benfotiamine and Cognitive Decline in Alzheimer's Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial
J Alzheimers Dis . 2020 Oct 16. doi: 10.3233/JAD-200896. Online ahead of print.
Abstract on PubMed
Ratan Lab
PUBLICATION: 
Journal Article
Yujia Zhai, Yingxin Chen, Saravanan S. Karuppagounder, Amit Kumar, Nandini Kundu, Ishraq Alim, Stephanie Taylor, Craig E. Brown, Xiang Luo, Yi-Fang Li, Dawei Lian, Yang Chen, Hilda Ahnstedt, Louise D. McCullough, Rong-Rong He, Rajiv R. Ratan
Tilorone, an oral antiviral agent utilized in humans, preconditions against transient ischemia in mice
Conditioning Medicine 2020. 3(1): 1-8.
Full-Text on Conditioning Medicine
Ratan Lab
PUBLICATION: 
Journal Article
Aimé P, Karuppagounder SS, Rao A, Chen Y, Burke RE, Ratan RR, Greene LA.
The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease.
Neurobiol Dis. 2020 Mar;136:104725. doi: 10.1016/j.nbd.2019.104725. Epub 2020 Jan 3.
Full-Text on Pubmed
Willis Lab
NEWS: 
Award
October 7, 2019
Dr. Dianna Willis to Collaborate on a Pain Treatment Project Granted by NIH HEAL Funding
Professors of Weill Cornell Medicine, the Burke Neurological Institute, and the Feil Family Brain and Mind Research Institute, have been awarded a grant from the National Institutes of Health (NIH) for a project to develop a non-opioid, non-addicting medicine for a hard-to-treat form of pain called neuropathic pain.
Photo of Dianna E. Willis, Ph.D., as Director of Research for the Burke-Blythedale Pediatric Neuroscience Research Collaboration
Willis Lab
GRANT: 
Federal
September 30, 2019 to July 31, 2021
Novel HCN1-Selective Small Molecule Inhibitors for the Treatment of Neuropathic Pain
Funding Status: 
Active Project
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Grant Number: 
UG3NS114947-01
Investigators: 
Peter A. Goldstein, M.D.
Principal Investigator
Dianna E. Willis, Ph.D.
Co-Investigator
NEWS: 
Story
August 26, 2019
How Robots Are Improving the Lives of Patients with Spinal Cord Injuries at Burke Neurological Institute
When you first meet Jamie Petrone, it is impossible not to notice her engaging smile and friendly personality. The 42-year-old has an optimistic outlook on life which is a bit surprising given her diagnosis of transverse myelopathy (TM), a type of spinal cord injury that has caused her to use a wheelchair for much of her life.
Jamie walking with EKSO robot

Causes

Neurodegenerative Diseases, Stroke, Spinal Cord Injury, Retinal Degenerative Diseases, Cognitive Recovery, Vision Recovery