Drug Discovery

Impact

NEWS:

In the Media

December 29, 2020

Benfotiamine and Cognitive Decline in Alzheimer's Disease Study Listed as a Top Non-Pandemic Advances in Health Care During 2020

Media Outlet:

CNN Health

Benfotiamine and Cognitive Decline in Alzheimer's Disease, a small exploratory clinical trial, conducted by Dr. Gary E. Gibson’s laboratory at the Burke Neurological Institute is listed in CNN Health’s article on ”Top 2020 health stories you may have missed because of Covid-19” under Advances in Alzheimer’s.

Gibson Lab

NEWS:

Article

November 25, 2020

New Data Suggests Raising Vitamin B1 Levels very high Helps People Living with mild Alzheimer’s Disease

A small exploratory clinical trial conducted by Dr. Gary E. Gibson’s laboratory at the Burke Neurological Institute in collaboration with physicians at the Burke Rehabilitation Hospital, suggests that Benfotiamine is safe and potentially efficacious in improving cognitive outcomes among people living with Mild Cognitive Impairment and mild Alzheimer’s disease (AD).

Ratan Lab

PUBLICATION:

Review

Orjon Rroji, Amit Kumar, Saravanan S Karuppagounder, Rajiv R Ratan

Epigenetic regulators of neuronal ferroptosis identify novel therapeutics for neurological diseases: HDACs, transglutaminases, and HIF prolyl hydroxylases

Neurobiol Dis . 2020 Oct 27;105145. doi: 10.1016/j.nbd.2020.105145. Online ahead of print.

Abstract on PubMed

Gibson Lab

PUBLICATION:

Manuscript

Gary E Gibson, José A Luchsinger, Rosanna Cirio, Huanlian Chen, Jessica Franchino-Elder, Joseph A Hirsch, Lucien Bettendorff, Zhengming Chen, Sarah Flowers, Linda Gerber, Thomas Grandville, Nicole Schupf, Hui Xu, Yaakov Stern, Christian Habeck, Barry Jordan, Pasquale Fonzetti

Benfotiamine and Cognitive Decline in Alzheimer's Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial

J Alzheimers Dis . 2020 Oct 16. doi: 10.3233/JAD-200896. Online ahead of print.

Abstract on PubMed

Ratan Lab

PUBLICATION:

Journal Article

Yujia Zhai, Yingxin Chen, Saravanan S. Karuppagounder, Amit Kumar, Nandini Kundu, Ishraq Alim, Stephanie Taylor, Craig E. Brown, Xiang Luo, Yi-Fang Li, Dawei Lian, Yang Chen, Hilda Ahnstedt, Louise D. McCullough, Rong-Rong He, Rajiv R. Ratan

Tilorone, an oral antiviral agent utilized in humans, preconditions against transient ischemia in mice

Conditioning Medicine 2020. 3(1): 1-8.

Full-Text on Conditioning Medicine

Ratan Lab

PUBLICATION:

Journal Article

Aimé P, Karuppagounder SS, Rao A, Chen Y, Burke RE, Ratan RR, Greene LA.

The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease.

Neurobiol Dis. 2020 Mar;136:104725. doi: 10.1016/j.nbd.2019.104725. Epub 2020 Jan 3.

Full-Text on Pubmed

Willis Lab

NEWS:

Award

October 7, 2019

Dr. Dianna Willis to Collaborate on a Pain Treatment Project Granted by NIH HEAL Funding

Professors of Weill Cornell Medicine, the Burke Neurological Institute, and the Feil Family Brain and Mind Research Institute, have been awarded a grant from the National Institutes of Health (NIH) for a project to develop a non-opioid, non-addicting medicine for a hard-to-treat form of pain called neuropathic pain.

Willis Lab

GRANT:

Federal

September 30, 2019 to July 31, 2021

Novel HCN1-Selective Small Molecule Inhibitors for the Treatment of Neuropathic Pain

Funding Status:

Active Project

National Institutes of Health (NIH)

National Institute of Neurological Disorders and Stroke (NINDS)

Grant Number:

UG3NS114947-01

Investigators:

Peter A. Goldstein, M.D.

Principal Investigator

Dianna E. Willis, Ph.D.

Co-Investigator

NEWS:

Story

August 26, 2019

How Robots Are Improving the Lives of Patients with Spinal Cord Injuries at Burke Neurological Institute

When you first meet Jamie Petrone, it is impossible not to notice her engaging smile and friendly personality. The 42-year-old has an optimistic outlook on life which is a bit surprising given her diagnosis of transverse myelopathy (TM), a type of spinal cord injury that has caused her to use a wheelchair for much of her life.

Kitago Lab / Ratan Lab

PUBLICATION:

Journal Article

Joshua Silverstein, Mar Cortes, Katherine Z. Tsagaris, Alejandra Climent, Linda M. Gerber, Clara Oromendia, Pasquale Fonzetti, Rajiv R. Ratan, Tomoko Kitago, Marco Iacoboni, Allan Wu, Bruce H. Dobkin and Dylan J. Edwards

Paired Associative Stimulation as a Tool to Assess Plasticity Enhancers in Chronic Stroke

Frontiers in Neuroscience, section Neural Technology. 15 Jul 2019. doi: 10.3389/fnins.2019.00792

Abstract on Frontiers

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Drug Discovery

Impact

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