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Drug Discovery

Impact

PUBLICATION: 
Opinion Article
Gary E Gibson, Howard H Feldman, Sheng Zhang, Sarah A Flowers, José A Luchsinger
Front Med (Lausanne). 2022 Oct 4;9:1033272. doi: 10.3389/fmed.2022.1033272. eCollection 2022.
Full-Text on Frontiers
PUBLICATION: 
Journal Article
NM Alam, RM Douglas, GT Prusky
Dis Model Mech . 2022 Mar 1;15(3):dmm048256. doi: 10.1242/dmm.048256. Epub 2022 Feb 21.
Full-Text on PMC
NEWS: 
Article
Today, scientists still do not know the cause of Alzheimer’s disease (AD), yet decades of research advancements give hope to the possibility of slowing down early-onset of AD. Benfotiamine, a therapeutic drug that raises blood vitamin B1, levels very high, was recently tested as a pilot clinical study conducted by the Gibson Lab at the Burke Neurological Institute.
Gibson Team in the Lab
NEWS: 
In the Media
Media Outlet: 
CNN Health
Benfotiamine and Cognitive Decline in Alzheimer's Disease, a small exploratory clinical trial, conducted by Dr. Gary E. Gibson’s laboratory at the Burke Neurological Institute is listed in CNN Health’s article on ”Top 2020 health stories you may have missed because of Covid-19” under Advances in Alzheimer’s.
Gibson Team in the Lab
NEWS: 
Article
A small exploratory clinical trial conducted by Dr. Gary E. Gibson’s laboratory at the Burke Neurological Institute in collaboration with physicians at the Burke Rehabilitation Hospital, suggests that Benfotiamine is safe and potentially efficacious in improving cognitive outcomes among people living with Mild Cognitive Impairment and mild Alzheimer’s disease (AD).
Photo of Gibson Lab
PUBLICATION: 
Review
Orjon Rroji, Amit Kumar, Saravanan S Karuppagounder, Rajiv R Ratan
Neurobiol Dis. 2021 Jan;147:105145. doi: 10.1016/j.nbd.2020.105145. Epub 2020 Oct 28.
Abstract on PubMed
PUBLICATION: 
Manuscript
Gary E Gibson, José A Luchsinger, Rosanna Cirio, Huanlian Chen, Jessica Franchino-Elder, Joseph A Hirsch, Lucien Bettendorff, Zhengming Chen, Sarah Flowers, Linda Gerber, Thomas Grandville, Nicole Schupf, Hui Xu, Yaakov Stern, Christian Habeck, Barry Jordan, Pasquale Fonzetti
J Alzheimers Dis. 2020;78(3):989-1010. doi: 10.3233/JAD-200896. Author manuscript; available in PMC 2021 Feb 12.
Full-Text on Pubmed
PUBLICATION: 
Journal Article
Yujia Zhai, Yingxin Chen, Saravanan S. Karuppagounder, Amit Kumar, Nandini Kundu, Ishraq Alim, Stephanie Taylor, Craig E. Brown, Xiang Luo, Yi-Fang Li, Dawei Lian, Yang Chen, Hilda Ahnstedt, Louise D. McCullough, Rong-Rong He, Rajiv R. Ratan
Conditioning Medicine 2020. 3(1): 1-8.
Full-Text on Conditioning Medicine
PUBLICATION: 
Journal Article
Aimé P, Karuppagounder SS, Rao A, Chen Y, Burke RE, Ratan RR, Greene LA.
Neurobiol Dis. 2020 Mar;136:104725. doi: 10.1016/j.nbd.2019.104725. Epub 2020 Jan 3.
Full-Text on Pubmed
NEWS: 
Award
Professors of Weill Cornell Medicine, the Burke Neurological Institute, and the Feil Family Brain and Mind Research Institute, have been awarded a grant from the National Institutes of Health (NIH) for a project to develop a non-opioid, non-addicting medicine for a hard-to-treat form of pain called neuropathic pain.
Photo of Dianna E. Willis, Ph.D., as Director of Research for the Burke-Blythedale Pediatric Neuroscience Research Collaboration