Cho Lab

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Neuro-Immune Interaction in Stroke Laboratory

Supplementary Movie Whole Brain Imaging Acut 3D

Although stroke is a primary cause of disability and death in the U.S., few options exist for treating patients who have had a stroke. The paucity of treatment options has prompted the field to focus on identification and validation of potential targets for developing treatment strategies. There have been numerous translational failures based on acute neuroprotective strategies in preclinical stroke studies. In addressing the translational gap, our research program has investigated comorbidity-modified stroke pathology in animals including hyperlipidemic, diabetic and obese conditions. Inclusion of these comorbidities in our experimental model of stroke provided understanding in disparities of stroke pathology between normal and metabolically compromised conditions. We have defined immune mechanisms involving neural inflammation and tissue repair processes using immunologic, molecular and system approaches and have proposed intervention strategies tailored to specific comorbid conditions.

AJ5 SC2a Stitched

Despite stroke being historically considered a CNS event, peripheral immunity is altered by cerebral ischemia and influences the progression of brain injury in stroke. By establishing a long-term stroke recovery model in an experimental animal model of stroke, we have addresses pathology and recovery/remodeling processes in a comprehensive context of stroke, with specific focus on understanding of neuro-immune interactions between CNS and peripheral system from acute to recovery phases of stroke. The formulated immune-based strategies aim at promote functional recovery in chronic stroke facilitates our translation-focused preclinical program for future clinical validation and application.

Featured Research Projects

RESEARCH PROJECT: 
In Progress

Stroke elicits excessive immune activation in the injured brain tissue.

RESEARCH PROJECT: 
In Progress

Despite a well-documented role of CD36 in the pathogenesis of conditions such as atherosclerosis, inflammation and lipid metabolism, its role in cerebral ischemic injury had not been recognized at the time I initiated the st

RESEARCH PROJECT: 
In Progress

The recurring failure to translate neuroprotective strategies in animal models into clinical settings prompted us to reevaluate existing preclinical stroke models.

RESEARCH PROJECT: 
In Progress

Studies to understand repair/recovery mechanisms that promote functional recovery have emerged. Genetics are among several factors that influence stroke recovery.

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Sunghee Cho, Ph.D.

Conditions & Recovery

Stroke icon
Every 40 seconds someone has a stroke.
Cognitive Recovery icon
Remember and talk clearly.
Motor Recovery Icon
Write and walk again.