Yoshida Lab

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Laboratory for Neural Connectivity Development in Physiology and Disease

The Yoshida lab is interested in understanding neural circuits to control movement (such as locomotion and skilled movements) which is one of the major final outputs of the mammalian central nervous system. Simple, repetitive locomotor activities require only spinal circuits since central pattern generators within the spinal cord regulate and coordinate the different muscle groups, whereas skilled movements require finer control and modulation of muscle activity, which is achieved through brain signals traveling through descending circuits to spinal interneurons. Disruption of brain-spinal circuit communication by injury or disease causes severe motor deficits. Therefore, it is crucial to understand how descending circuits control motor behaviors in intact animals as we search for new therapies for patients with spinal cord injuries or motor disorders. The long-term goal of our research is to understand the formation, function, evolution, and regeneration of distinct motor circuits, in the context of locomotion and skilled behaviors.

Cover image on Development June 2021

Motor neurons are retrogradely labelled with FITC-Dextran (green). Axons and presynaptic terminals of proprioceptive sensory neurons are labelled with anti-parvalbumin (red) and anti-vGlut1 (blue) antibodies, respectively.



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Yutaka Yoshida, Ph.D.

Conditions & Recovery

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Around the world, between 300,000 and 500,000 people are living with a SCI.
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Write and walk again.