Drug Discovery

Impact

PUBLICATION:

Journal Article

Senthilkumar KS, Saravanan KS, Chandra G, Sindhu KM, Jayakrishnan A, Mohanakumar KP.

Unilateral implantation of dopamine-loaded biodegradable hydrogel in the striatum attenuates motor abnormalities in the 6-hydroxydopamine model of hemi-parkinsonism.

Behav Brain Res. 2007 Nov 22;184(1):11-8.

Abstract on PubMed

Gibson Lab

PUBLICATION:

Review

Gibson GE, Blass JP.

Thiamine-dependent processes and treatment strategies in neurodegeneration.

Antioxid Redox Signal. 2007 Oct;9(10):1605-19. Review.

Abstract on PubMed

PUBLICATION:

Journal Article

Banerjee R, Sreetama S, Saravanan KS, Dey SN, Mohanakumar KP.

Apoptotic mode of cell death in substantia nigra following intranigral infusion of the parkinsonian neurotoxin, MPP+ in Sprague-Dawley rats: cellular, molecular and ultrastructural evidences.

Neurochem Res. 2007 Jul;32(7):1238-47.

Abstract on PubMed

PUBLICATION:

Journal Article

Zhong J, Li X, McNamee C, Chen AP, Baccarini M, Snider WD.

Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo.

Nat Neurosci. 2007 May;10(5):598-607.

Abstract on PubMed

PUBLICATION:

Journal Article

Saravanan KS, Sindhu KM, Mohanakumar KP.

Melatonin protects against rotenone-induced oxidative stress in a hemiparkinsonian rat model.

J Pineal Res. 2007 Apr;42(3):247-53.

Abstract on PubMed

Gibson Lab

PUBLICATION:

Journal Article

Blass JP, Gibson GE.

Correlations of disability and biologic alterations in Alzheimer brain and test of significance by a therapeutic trial in humans.

J Alzheimers Dis. 2006 Jul;9(2):207-18.

Abstract on PubMed

Gibson Lab

PUBLICATION:

Journal Article

Zhang L, Cooper AJ, Krasnikov BF, Xu H, Bubber P, Pinto JT, Gibson GE, Hanigan MH.

Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells.

Biochemistry. 2006 Jul 25;45(29):8959-71.

Full-Text on PubMed

PUBLICATION:

Journal Article

Banerjee R, Sreetama S, Saravanan KS, Chandra G, Nath De S, Mohanakumar KP.

Intrastriatal infusion of the Parkinsonian neurotoxin, MPP(+), induces damage of striatal cell nuclei in Sprague-Dawley rats.

J Chem Neuroanat. 2006 Dec;32(2-4):90-100.

Abstract on PubMed

PUBLICATION:

Journal Article

Sindhu KM, Banerjee R, Senthilkumar KS, Saravanan KS, Raju BC, Rao JM, Mohanakumar KP.

Rats with unilateral median forebrain bundle, but not striatal or nigral, lesions by the neurotoxins MPP+ or rotenone display differential sensitivity to amphetamine and apomorphine.

Pharmacol Biochem Behav. 2006 Jun;84(2):321-9.

Abstract on PubMed

PUBLICATION:

Journal Article

Sagdullaev BT, McCall MA, Lukasiewicz PD.

Presynaptic inhibition modulates spillover, creating distinct dynamic response ranges of sensory output.

Neuron. 2006 Jun 15;50(6):923-35.

Abstract on PubMed

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Drug Discovery

Impact

Causes