Drug Discovery

Impact

PUBLICATION:

Review

Langley B, Gensert JM, Beal MF, Ratan RR.

Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents.

Curr Drug Targets CNS Neurol Disord. 2005 Feb;4(1):41-50. Review.

Abstract on PubMed

PUBLICATION:

Journal Article

Rodrigues JP, Edwards DJ, Walters SE, Byrnes ML, Thickbroom G, Stell R, Mastaglia FL.

Gabapentin can improve postural stability and quality of life in primary orthostatic tremor.

Mov Disord. 2005 Jul;20(7):865-70.

Abstract on PubMed

Gibson Lab

PUBLICATION:

Review

Gibson GE, Huang HM.

Mitochondrial enzymes and endoplasmic reticulum calcium stores as targets of oxidative stress in neurodegenerative diseases.

J Bioenerg Biomembr. 2004 Aug;36(4):335-40. Review.

Abstract on PubMed

Gibson Lab

PUBLICATION:

Review

Ke ZJ, Gibson GE.

Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism.

Neurochem Int. 2004 Jul-Aug;45(2-3):361-9. Review.

Abstract on PubMed

Gibson Lab

PUBLICATION:

Journal Article

Klivenyi P, Starkov AA, Calingasan NY, Gardian G, Browne SE, Yang L, Bubber P, Gibson GE, Patel MS, Beal MF.

Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity.

J Neurochem. 2004 Mar;88(6):1352-60.

Abstract on PubMed

Cho Lab

PUBLICATION:

Journal Article

Park EM, Joh TH, Volpe BT, Chu CK, Song G, Cho S.

A neuroprotective role of extracellular signal-regulated kinase in N-acetyl-O-methyldopamine-treated hippocampal neurons after exposure to in vitro and in vivo ischemia.

Neuroscience. 2004;123(1):147-54.

Abstract on PubMed

Ratan Lab

PUBLICATION:

Journal Article

Ratan RR.

Mining genome databases for therapeutic gold: SIM2 is a novel target for treatment of solid tumors.

Trends Pharmacol Sci. 2003 Oct;24(10):508-10. No abstract available.

PubMed

PUBLICATION:

Journal Article

Mehta H, Saravanan KS, Mohanakumar KP.

Serotonin synthesis inhibition in olivo-cerebellar system attenuates harmaline-induced tremor in Swiss albino mice.

Behav Brain Res. 2003 Oct 17;145(1-2):31-6.

Abstract on PubMed

Gibson Lab

PUBLICATION:

Journal Article

Huang HM, Ou HC, Xu H, Chen HL, Fowler C, Gibson GE.

Inhibition of alpha-ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase-3 activation, and necrotic cell death.

J Neurosci Res. 2003 Oct 15;74(2):309-17.

Abstract on PubMed

PUBLICATION:

Journal Article

Sairam K, Saravanan KS, Banerjee R, Mohanakumar KP.

Non-steroidal anti-inflammatory drug sodium salicylate, but not diclofenac or celecoxib, protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats.

Brain Res. 2003 Mar 21;966(2):245-52.

Abstract on PubMed

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Drug Discovery

Impact

Causes