Drug Discovery

Impact

PUBLICATION:

Journal Article

Smirnova NA, Rakhman I, Moroz N, Basso M, Payappilly J, Kazakov S, Hernandez-Guzman F, Gaisina IN, Kozikowski AP, Ratan RR, Gazaryan IG.

Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation.

Chem Biol. 2010 Apr 23;17(4):380-91. doi: 10.1016/j.chembiol.2010.03.008.

Full-Text on PubMed

Willis Lab / Ratan Lab

PUBLICATION:

Journal Article

Ma TC, Campana A, Lange PS, Lee HH, Banerjee K, Bryson JB, Mahishi L, Alam S, Giger RJ, Barnes S, Morris SM Jr, Willis DE, Twiss JL, Filbin MT, Ratan RR.

A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway.

J Neurosci. 2010 Jan 13;30(2):739-48. doi: 10.1523/JNEUROSCI.5266-09.2010.

Full-Text on PubMed

Ratan Lab

PUBLICATION:

Review

Sleiman SF, Basso M, Mahishi L, Kozikowski AP, Donohoe ME, Langley B, Ratan RR.

Putting the 'HAT' back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions.

Expert Opin Investig Drugs. 2009 May;18(5):573-84. doi: 10.1517/13543780902810345 . Review.

Full-Text on PubMed

Gibson Lab

PUBLICATION:

Review

Gibson GE, Karuppagounder SS, Shi Q.

Oxidant-induced changes in mitochondria and calcium dynamics in the pathophysiology of Alzheimer's disease.

Ann N Y Acad Sci. 2008 Dec;1147:221-32. doi: 10.1196/annals.1427.038. Review.

Full-Text on PubMed

Ratan Lab

PUBLICATION:

Journal Article

Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H, Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, Sen C, Beattie MS, Hart RP, Grumet M, Sun D, Freeman RS, Semenza GL, et al.

Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.

Ann N Y Acad Sci. 2008 Dec;1147:383-94. doi: 10.1196/annals.1427.033.

Full-Text on PubMed

Cho Lab / Ratan Lab

PUBLICATION:

Journal Article

Langley B, D'Annibale MA, Suh K, Ayoub I, Tolhurst A, Bastan B, Yang L, Ko B, Fisher M, Cho S, Beal MF, Ratan RR.

Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection.

J Neurosci. 2008 Jan 2;28(1):163-76. doi: 10.1523/JNEUROSCI.3200-07.2008.

Full-Text on PubMed

PUBLICATION:

Journal Article

Thomas B, Saravanan KS, Mohanakumar KP.

In vitro and in vivo evidences that antioxidant action contributes to the neuroprotective effects of the neuronal nitric oxide synthase and monoamine oxidase-B inhibitor, 7-nitroindazole.

Neurochem Int. 2008 May;52(6):990-1001. doi: 10.1016/j.neuint.2007.10.012.

Abstract on PubMed

Prusky Lab

PUBLICATION:

Journal Article

McGill TJ, Prusky GT, Douglas RM, Yasumura D, Matthes MT, Nune G, Donohue-Rolfe K, Yang H, Niculescu D, Hauswirth WW, Girman SV, Lund RD, Duncan JL, LaVail MM.

Intraocular CNTF reduces vision in normal rats in a dose-dependent manner.

Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5756-66.

Abstract on PubMed

Ratan Lab / Cho Lab

PUBLICATION:

Review

Ratan RR, Siddiq A, Smirnova N, Karpisheva K, Haskew-Layton R, McConoughey S, Langley B, Estevez A, Huerta PT, Volpe B, Roy S, Sen CK, Gazaryan I, Cho S, Fink M, LaManna J.

Harnessing hypoxic adaptation to prevent, treat, and repair stroke.

J Mol Med (Berl). 2007 Dec;85(12):1331-8. Review.

Full-Text on PubMed

PUBLICATION:

Journal Article

Banerjee R, Saravanan KS, Thomas B, Sindhu KM, Mohanakumar KP.

Evidence for hydroxyl radical scavenging action of nitric oxide donors in the protection against 1-methyl-4-phenylpyridinium-induced neurotoxicity in rats.

Neurochem Res. 2008 Jun;33(6):985-95.

Abstract on PubMed

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Drug Discovery

Impact

Causes