Ratan Lab
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Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.

Journal Article
Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H, Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, Sen C, Beattie MS, Hart RP, Grumet M, Sun D, Freeman RS, Semenza GL, et al.
Year Published: 
Ann N Y Acad Sci. 2008 Dec;1147:383-94. doi: 10.1196/annals.1427.033.
PMID:19076458 | PMCID:PMC2921907
Full-Text on PubMed


Conditions & Recovery

Spinal Cord Injury icon
Around the world, between 300,000 and 500,000 people are living with a SCI.
Stroke icon
Stroke is the leading cause of disability in the U.S.