A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway.

PUBLICATION:

Journal Article

Authors:

Ma TC, Campana A, Lange PS, Lee HH, Banerjee K, Bryson JB, Mahishi L, Alam S, Giger RJ, Barnes S, Morris SM Jr, Willis DE, Twiss JL, Filbin MT, Ratan RR.

Year Published:

2010

Publisher:

J Neurosci. 2010 Jan 13;30(2):739-48. doi: 10.1523/JNEUROSCI.5266-09.2010.

Identifiers:

PMID:20071539 | PMCID:PMC3554247

Full-Text on PubMed

Featured Researchers

Dianna E. Willis, Ph.D.

Associate Director

Lab Director

Laboratory for Axonal and RNA Biology

Assistant Professor

Weill Cornell Medicine

Rajiv R. Ratan, M.D., Ph.D.

Chief Executive Officer

Burke Professor, Associate Dean (affiliate)

Weill Cornell Medicine

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A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway.

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