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Saravanan S. Karuppagounder, Ph.D.
FACULTY - CORE

Saravanan S. Karuppagounder, Ph.D.

Director of the Spinal Cord Injury Core
Burke Neurological Institute
Instructor
Laboratory for Redox Biology and Neural Protection and Repair
Burke Neurological Institute
Instructor of Neuroscience
Weill Cornell Medicine

Biography

My research interests focus on the use of small molecule inhibitors of hypoxia inducible factor prolyl hydroxylases (HIF PHDs) as novel therapeutics for intracerebral hemorrhage. We have developed an in vitro model to mimic hemorrhagic stroke using hemin, which induces cell death in various neuronal cell types that is rescued by PHD inhibitors. We also utilize an in vivo rat or mice models for hemorrhagic stroke using autologous blood infusion or hemin. We are testing the efficacy of PHD inhibitors in these preclinical animal models using end points including brain edema volume, neuronal survival, and behavioral outcomes. Our findings suggest that PHD inhibitors are promising candidates for preventing cell death in hemorrhagic stroke.

Recent Publications

PUBLICATION: 
Journal Article
Yujia Zhai, Yingxin Chen, Saravanan S. Karuppagounder, Amit Kumar, Nandini Kundu, Ishraq Alim, Stephanie Taylor, Craig E. Brown, Xiang Luo, Yi-Fang Li, Dawei Lian, Yang Chen, Hilda Ahnstedt, Louise D. McCullough, Rong-Rong He, Rajiv R. Ratan
Conditioning Medicine 2020. 3(1): 1-8.
Full-Text on Conditioning Medicine
PUBLICATION: 
Journal Article
Aimé P, Karuppagounder SS, Rao A, Chen Y, Burke RE, Ratan RR, Greene LA.
Neurobiol Dis. 2020 Jan 3:104725. doi: 10.1016/j.nbd.2019.104725. [Epub ahead of print]
Abstract on PubMed
PUBLICATION: 
Journal Article
Ishraq Alim, Joseph T. Caulfield, Yingxin Chen, Vivek Swarup, Daniel H. Geschwind, Elena Ivanova, Javier Seravalli, Youxi Ai, Lauren H. Sansing, Emma J. Ste.Marie, Robert J. Hondal, Sushmita Mukherjee, John W. Cave, Botir T. Sagdullaev, Saravanan S. Karuppagounder, Rajiv R. Ratan
Cell. 2019 May 16;177(5):1262-1279.e25. doi: 10.1016/j.cell.2019.03.032. Epub 2019 May 2.
Abstract on CellPress