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Saravanan S. Karuppagounder, Ph.D.

Saravanan S. Karuppagounder, Ph.D.

Director of the Spinal Cord Injury Core
Burke Neurological Institute
Laboratory for Neural Redox Biology and Homeostatic Transcription
Burke Neurological Institute
Assistant Professor of Research in Neuroscience
Weill Cornell Medicine


My research interests focus on the use of small molecule inhibitors of hypoxia inducible factor prolyl hydroxylases (HIF PHDs) as novel therapeutics for intracerebral hemorrhage. We have developed an in vitro model to mimic hemorrhagic stroke using hemin, which induces cell death in various neuronal cell types that is rescued by PHD inhibitors. We also utilize an in vivo rat or mice models for hemorrhagic stroke using autologous blood infusion or hemin. We are testing the efficacy of PHD inhibitors in these preclinical animal models using end points including brain edema volume, neuronal survival, and behavioral outcomes. Our findings suggest that PHD inhibitors are promising candidates for preventing cell death in hemorrhagic stroke.

Recent Publications

Journal Article
Nandini Kundu, Amit Kumar, Carlo Corona, Yingxin Chen, Sonia Seth, Saravanan S. Karuppagounder, Rajiv R. Ratan
Brain Commun. 2022 May 24;4(3):fcac133. doi: 10.1093/braincomms/fcac133. eCollection 2022.
PDF on Oxford Academic
Marietta Zille, Juan A Oses-Prieto, Sara R Savage, Saravanan S Karuppagounder, Yingxin Chen, Amit Kumar, John H Morris, Karl A Scheidt, Alma L Burlingame, Rajiv R Ratan
J Neurosci. 2022 Mar 9;42(10):2065-2079. doi: 10.1523/JNEUROSCI.0923-20.2021. Epub 2022 Jan 5.
Abstract on PubMed
Amit Kumar, Manisha Vaish, Saravanan S Karuppagounder, Irina Gazaryan, John W Cave, Anatoly A Starkov, Elizabeth T Anderson, Sheng Zhang, John T Pinto, Austin M Rountree, Wang Wang, Ian R Sweet, Rajiv R Ratan
Elife. 2021 Oct 1;10:e72873. doi: 10.7554/eLife.72873.
Full-Text on Pubmed