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Saravanan S. Karuppagounder, Ph.D.

Saravanan S. Karuppagounder, Ph.D.

Director of the Spinal Cord Injury Core
Burke Neurological Institute
Laboratory for Neural Redox Biology and Homeostatic Transcription
Burke Neurological Institute
Assistant Professor of Research in Neuroscience
Weill Cornell Medicine


My research interests focus on the use of small molecule inhibitors of hypoxia inducible factor prolyl hydroxylases (HIF PHDs) as novel therapeutics for intracerebral hemorrhage. We have developed an in vitro model to mimic hemorrhagic stroke using hemin, which induces cell death in various neuronal cell types that is rescued by PHD inhibitors. We also utilize an in vivo rat or mice models for hemorrhagic stroke using autologous blood infusion or hemin. We are testing the efficacy of PHD inhibitors in these preclinical animal models using end points including brain edema volume, neuronal survival, and behavioral outcomes. Our findings suggest that PHD inhibitors are promising candidates for preventing cell death in hemorrhagic stroke.

Recent Publications

Amit Kumar, Manisha Vaish, Saravanan S Karuppagounder, Irina Gazaryan, John W Cave, Anatoly A Starkov, Elizabeth T Anderson, Sheng Zhang, John T Pinto, Austin M Rountree, Wang Wang, Ian R Sweet, Rajiv R Ratan
Elife. 2021 Oct 1;10:e72873. doi: 10.7554/eLife.72873.
Full-Text on Pubmed
Journal Article
George Z Wei, Sujata Saraswat Ohri, Nicolas K Khattar, Adam W Listerman, Catherine H Doyle, Kariena R Andres , Saravanan S Karuppagounder, Rajiv R Ratan, Scott R Whittemore, Michal Hetman
PLoS One. 2021 Apr 5;16(4):e0249591. doi: 10.1371/journal.pone.0249591. eCollection 2021.
Full-Text on Pubmed
Case Report
Michael H. Askenase, Brittany A. Goods, Hannah E. Beatty, Arthur F. Steinschneider, Sofia E. Velazquez, Artem Osherov, Margaret J. Landreneau, Shaina L. Carroll, Tho B. Tran, Victor S. Avram, Riley S. Drake, G. James Gatter, Jordan A. Massey, Saravanan S. Karuppagounder, Rajiv R. Ratan, Charles C. Matouk, Kevin N. Sheth, Wendy C. Ziai, Adrian R. Parry-Jones, Issam A. Awad, Mario Zuccarello, Richard E. Thompson, Jesse Dawson, Daniel F. Hanley, J. Christopher Love, Alex K. Shalek, Lauren H. Sansing, MISTIE III Consortium, ICHseq investigators
Science Immunology 2021 Feb 19;6(56):eabd6279. doi: 10.1126/sciimmunol.abd6279. Epub 2021 Feb 19.
Full-Text on Pubmed Science Immunology