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Cell Death

Impact

Ratan Lab
PUBLICATION: 
Review
Orjon Rroji, Amit Kumar, Saravanan S Karuppagounder, Rajiv R Ratan
Epigenetic regulators of neuronal ferroptosis identify novel therapeutics for neurological diseases: HDACs, transglutaminases, and HIF prolyl hydroxylases
Neurobiol Dis. 2021 Jan;147:105145. doi: 10.1016/j.nbd.2020.105145. Epub 2020 Oct 28.
Abstract on PubMed
Ratan Lab
NEWS: 
Article
May 22, 2020
Cell Chemical Biology Features Review Article on Ferroptosis in the Central Nervous System by Dr. Raj Ratan
May 6, 2020 – Featured on the cover of Cell Chemical Biology, a new and significant review article by Dr. Raj Ratan, Executive Director of the Burke Neurological Institute, examines “The Chemical Biology of Ferroptosis in the Central Nervous System.”
Cell Chemical Biology Cover May 2020
Ratan Lab
PUBLICATION: 
Manuscript
Goldberg DC, Fones L, Vivinetto AL, Caufield JT, Ratan RR, Cave JW.
Manipulating Adult Neural Stem and Progenitor Cells with G-Quadruplex Ligands
ACS Chem Neurosci. 2020 May 20;11(10):1504-1518. doi: 10.1021/acschemneuro.0c00194. Epub 2020 Apr 29.
Abstract on PubMed
Ratan Lab
PUBLICATION: 
Review
Rajiv R. Ratan
The Chemical Biology of Ferroptosis in the Central Nervous System
Cell Chem Biol. 2020 Mar 24. pii: S2451-9456(20)30081-7. doi: 10.1016/j.chembiol.2020.03.007. [Epub ahead of print]
Full-Text on Cell Chemical Biology
Ratan Lab
NEWS: 
In the Media
May 16, 2019
A New Strategy for Protecting the Brain After Strokes
Media Outlet: 
Weill Cornell Medicine Newsroom
The chemical element selenium, an essential nutrient for humans and other animals, protects the brain after a stroke and may be a basis for future stroke therapies, according to a study from scientists at Burke Neurological Institute and Weill Cornell Medicine.
Dr. Ratan in his lab
Ratan Lab
PRESENTATION: 
Invited Speaker
May 8, 2019
Twists and Turns (non-helical) on the Transcriptional Road to Oxidative Neuronal Death: Implications for Brain Protection and Repair
Venue: 
Department of Neurosciences, Lerner Research Institute at Cleveland Clinic
Featured Researchers: 
Rajiv R. Ratan, M.D., Ph.D.
Ratan Lab
PRESENTATION: 
Grand Rounds
May 3, 2019
Twists and Turns (non-helical) on the Transcriptional Road to Oxidative Neuronal Death: Implications for Brain Protection and Repair
Venue: 
Yale School of Medicine, Neurology Grand Rounds
Featured Researchers: 
Rajiv R. Ratan, M.D., Ph.D.
Ratan Lab
NEWS: 
Press Release
May 2, 2019
Transformational Selenium Peptide Provides New Nutritional Medicine for Treating Stroke
A team of scientists have discovered that selenium, a micronutrient, can help boost the antioxidant system on the heels of stroke in animals and suggests that a similar treatment could be used to limit brain damage in patients. Stroke is a leading cause of disability and death in the United States, occurring once every 40 seconds.
A team of scientists at the Burke Neurological Institute
Ratan Lab
PUBLICATION: 
Journal Article
Ishraq Alim, Joseph T. Caulfield, Yingxin Chen, Vivek Swarup, Daniel H. Geschwind, Elena Ivanova, Javier Seravalli, Youxi Ai, Lauren H. Sansing, Emma J. Ste.Marie, Robert J. Hondal, Sushmita Mukherjee, John W. Cave, Botir T. Sagdullaev, Saravanan S. Karuppagounder, Rajiv R. Ratan
Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke
Cell. 2019 May 16;177(5):1262-1279.e25. doi: 10.1016/j.cell.2019.03.032. Epub 2019 May 2.
Abstract on CellPress
Ratan Lab / Willis Lab
PUBLICATION: 
Manuscript
Marietta Zille, Amit Kumar, Nandini Kundu, Megan W. Bourassa, Victor S. C. Wong, Dianna Willis, Saravanan S. Karuppagounder and Rajiv R. Ratan
Ferroptosis in neurons and cancer cells is similar but differentially regulated by histone deacetylase inhibitors
eNeuro. 2019 Feb 15;6(1). pii: ENEURO.0263-18.2019. doi: 10.1523/ENEURO.0263-18.2019. eCollection 2019 Jan-Feb.
Full-Text on Pubmed

Causes

Motor Recovery, Pain & Sensory Recovery, Cognitive Recovery, Vision Recovery, Stroke, Spinal Cord Injury, Neurodegenerative Diseases