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Cell Death


May 6, 2020 – Featured on the cover of Cell Chemical Biology, a new and significant review article by Dr. Raj Ratan, Executive Director of the Burke Neurological Institute, examines “The Chemical Biology of Ferroptosis in the Central Nervous System.”
Cell Chemical Biology Cover May 2020
Goldberg DC, Fones L, Vivinetto AL, Caufield JT, Ratan RR, Cave JW.
ACS Chem Neurosci. 2020 Apr 29. doi: 10.1021/acschemneuro.0c00194. [Epub ahead of print]
Abstract on PubMed
Rajiv R. Ratan
Cell Chem Biol. 2020 Mar 24. pii: S2451-9456(20)30081-7. doi: 10.1016/j.chembiol.2020.03.007. [Epub ahead of print]
Full-Text on Cell Chemical Biology
In the Media
Media Outlet: 
Weill Cornell Medicine Newsroom
The chemical element selenium, an essential nutrient for humans and other animals, protects the brain after a stroke and may be a basis for future stroke therapies, according to a study from scientists at Burke Neurological Institute and Weill Cornell Medicine.
Dr. Ratan in his lab
Press Release
A team of scientists have discovered that selenium, a micronutrient, can help boost the antioxidant system on the heels of stroke in animals and suggests that a similar treatment could be used to limit brain damage in patients. Stroke is a leading cause of disability and death in the United States, occurring once every 40 seconds.
A team of scientists at the Burke Neurological Institute
Journal Article
Ishraq Alim, Joseph T. Caulfield, Yingxin Chen, Vivek Swarup, Daniel H. Geschwind, Elena Ivanova, Javier Seravalli, Youxi Ai, Lauren H. Sansing, Emma J. Ste.Marie, Robert J. Hondal, Sushmita Mukherjee, John W. Cave, Botir T. Sagdullaev, Saravanan S. Karuppagounder, Rajiv R. Ratan
Cell. 2019 May 16;177(5):1262-1279.e25. doi: 10.1016/j.cell.2019.03.032. Epub 2019 May 2.
Abstract on CellPress
Marietta Zille, Amit Kumar, Nandini Kundu, Megan W. Bourassa, Victor S. C. Wong, Dianna Willis, Saravanan S. Karuppagounder and Rajiv R. Ratan
eNeuro. 2019 Feb 15;6(1). pii: ENEURO.0263-18.2019. doi: 10.1523/ENEURO.0263-18.2019. eCollection 2019 Jan-Feb.
Full-Text on Pubmed