Cell Death

Impact

Ratan Lab

PRESENTATION:

Conference

November 26, 2018 to November 30, 2018

Cold Spring Harbor Asia: Second Prize Fellowship for Short Talk

Venue:

Cold Spring Harbor Asia Conference on Iron, Reactive Oxygen Species & Ferroptosis in Life, Death & Disease,

Featured Researchers:

Ishraq Alim, Ph.D.

Ratan Lab

NEWS:

Award

May 31, 2018

Dr. Ratan Accepts Invitation to Serve as a Member of the Neural Oxidative Metabolism and Death Study Section, Center for Scientific Review.

Nation Institutes of Health (NIH)

With great honor, Dr. Raj Ratan, executive director of Burke Neurological Institute, has been invited to serve as a member of the Neural Oxidative Metabolism and Death Study Section, Center for Scientific Review for the term beginning July 01, 2018 and ending June 30, 2024.

Ratan Lab

PUBLICATION:

Journal Article

Zille M, Karuppagounder SS, Chen Y, Gough PJ, Bertin J, Finger J, Milner TA, Jonas EA, Ratan RR.

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis.

Zille M, Karuppagounder SS, Chen Y, Gough PJ, Bertin J, Finger J, Milner TA, Jonas EA, Ratan RR. Stroke. 2017 Apr;48(4):1033-1043. doi: 10.1161/STROKEAHA.116.015609. Epub 2017 Mar 1.

Abstract on PubMed

Gibson Lab

PUBLICATION:

Journal Article

Chen H, Denton TT, Xu H, Calingasan N, Beal MF, Gibson GE.

Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?

J Neurochem. 2016 Dec;139(5):823-838. doi: 10.1111/jnc.13836.

Abstract on PubMed

Ratan Lab

RESEARCH PROJECT:

In Progress

Use of small molecule inhibitors of hypoxia inducible factor prolyl hydroxylases (HIF PHDs) as novel therapeutics for intracerebral hemorrhage

Researchers have developed an in vitromodel to mimic hemorrhagic stroke using hemin, which induces cell death in various neuronal cell types that is rescued by PHD inhibitors.

Ratan Lab

RESEARCH PROJECT:

In Progress

Determining Cell Death Mechanisms after Experimental Hemorrhagic Stroke In Vitro and In Vivo

Intracerebral hemorrhage (ICH) accounts for about 15% of all strokes and has the highest mortality rates among strokes with up to 50% within 30 days after the insult. It is known to increase intracranial pressure and is associated with excitotoxicity, oxidative stress, and inflammation.

Ratan Lab

PUBLICATION:

Journal Article

Neitemeier S, Dolga AM, Honrath B, Karuppagounder SS, Alim I, Ratan RR, Culmsee C.

Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis.

Cell Death Dis. 2016 May 5;7:e2214. doi: 10.1038/cddis.2016.107.

Abstract on PubMed

Gibson Lab

GRANT:

Federal

April 15, 2016 to March 31, 2021

The Tricarboxylic Acid (Tca) Cycle in Neurodegeneration