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Genetics

Impact

Cho Lab
NEWS: 
Award
June 18, 2018
JBC’s Editors’ Picks: Inhibition of CD36 reduces visceral fat accumulation and improves insulin resistance in diet-induced obese BDNF Val66Met mice
Journal of Biological Chemistry

On June 18, a paper with an aim to reduce obesity authored by Burke Neurological Institute’s Preclinical Stroke Modeling Laboratory was determined to be in the top 2 percent of manuscripts with significance and overall importance for the yea

JBC’s Editors’ Picks: Inhibition of CD36 reduces visceral fat accumulation and improves insulin resistance in diet-induced obese BDNF Val66Met mice
Cho Lab
PUBLICATION: 
Editors’ Picks
Yang J, Park KW, Cho S.
Inhibition of CD36 reduces visceral fat accumulation and improves insulin resistance in diet-induced obese BDNF Val66Met mice
J Biol Chem. 2018 Aug 24;293(34):13338-13348. doi: 10.1074/jbc.RA118.002405. Epub 2018 Jun 18.
Full-Text on Pubmed
Ratan Lab
PUBLICATION: 
Journal Article
Karuppagounder SS, Zhai Y, Chen Y, He R, Ratan RR.
The interferon response as a common final pathway for many preconditioning stimuli: unexpected crosstalk between hypoxic adaptation and antiviral defense.
Cond Med. 2018 Apr;1(4):143-150. Epub 2018 Jun 15.
Abstract on PubMed
Yoshida Lab
PUBLICATION: 
Journal Article
Yoshida Y, Isa T.
Neural and genetic basis of dexterous hand movements.
Curr Opin Neurobiol. 2018 Oct;52:25-32. doi: 10.1016/j.conb.2018.04.005. Epub 2018 Apr 24.
Abstract on PubMed
EVENT: 
Weekly Seminar | Not Open to the Public
Human Genetic Investigation as a Pipeline for Drug Discovery for Cerebrovascular Disease
Tuesday, February 13, 2018 - 12:30pm
Billings Building – Rosedale
Jonathan Rosand, MD, MSc
Jonathan Rosand, MD, MSc
NEWS: 
Press Release
July 19, 2017
Lowey Announces $3.1 Million in NIH Funding for Burke Medical Research Institute
National Institutes of Health’s (NIH) National Institute of Neurological Disorders and Stroke (NINDS)

White Plains, NY -- Congresswoman Nita Lowey (D-NY17/Rockland-Westchester) today announced $3,125,875 in federal funding over the next five years for Burke Medical Research Institute (BMRI) in White Plains.

Dr. Jian Zhong & BMRI Colleagues Awarded funding to visualize reformation of spinal circuits as they are happening.
Ratan Lab
PUBLICATION: 
Journal Article
Smirnova NA, Kaidery NA, Hushpulian DM, Rakhman II, Poloznikov AA, Tishkov VI, Karuppagounder SS, Gaisina IN, Pekcec A, Leyen KV, Kazakov SV, Yang L, Thomas B, Ratan RR, Gazaryan IG.
Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson's Disease.
Aging Dis. 2016 Dec 1;7(6):745-762. doi: 10.14336/AD.2016.0505. eCollection 2016 Dec.
Full-Text on PubMed
Gibson Lab
RESEARCH PROJECT: 
In Progress
KGDHC and Neurodegenerative Disease

Mitochondrial dysfunction and oxidative stress are consistent features of multiple neurodegenerative diseases including Alzheimer’s disease (AD).

PUBLICATION: 
Journal Article
Lu Q, Ganjawala TH, Ivanova E, Cheng JG, Troilo D, Pan ZH.
AAV-mediated transduction and targeting of retinal bipolar cells with improved mGluR6 promoters in rodents and primates.
Gene Ther. 2016 Aug;23(8-9):680-9. doi: 10.1038/gt.2016.42.
Full-Text on PubMed
GRANT: 
Non-Federal
January 1, 2016 to February 28, 2019
Promoting Intrinsic Growth Competency of Injured Neurons Using Genetic and Small Molecule Approaches
Funding Status: 
Completed Project
New York State Department of Health (NYSDOH)
Spinal Cord Injury Research Board (SCIRB)
Investigators: 
Jian Zhong, Ph.D.
Principal Investigator
Mariel Voutounou, Ph.D.
Postdoctoral Research Fellow
Francesco Boato, Ph.D.
Postdoctoral Research Fellow

Causes

Motor Recovery, Pain & Sensory Recovery, Vision Recovery, Neurodegenerative Diseases, Retinal Degenerative Diseases