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Human Genetic Investigation as a Pipeline for Drug Discovery for Cerebrovascular Disease

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Jonathan Rosand, MD, MSc
Professor of Neurology, Harvard Medical School
Medical Director, Neuroscience Intensive Care Unit, Massachusetts General Hospital

Research Abstract:

The Rosand lab is housed within the MGH Center for Genomic Medicine and the Broad Institute of MIT and Harvard. The hallmark of their work is the analysis phenotypic, imaging, and genetic data from patients with cerebrovascular disease to test hypothesis about the underlying biology of the vascular disorders that both give rise to stroke and influence outcome from stroke. In the spring of 2007 Dr. Rosand established the International Stroke Genetics Consortium. The ISGC has grown into the leading force in stroke genetics, with more than 80 members drawn from six continents and is responsible for all of the enduring genetic discoveries in common forms of stroke. Most recently Dr. Rosand’s team launched a global platform for the analysis and sharing of genetic and phenotypic data.

Jonathan Rosand, MD, MSc Figure


Biffi A, Anderson CD, Battey TW, Ayres AM, Greenberg SM, Viswanathan A, Rosand J.
Association Between Blood Pressure Control and Risk of Recurrent Intracerebral Hemorrhage.
JAMA. 2015 Sep 1;314(9):904-12. doi: 10.1001/jama.2015.10082.
NINDS Stroke Genetics Network (SiGN); International Stroke Genetics Consortium (ISGC).
Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.
Lancet Neurol. 2016 Feb;15(2):174-184. doi: 10.1016/S1474-4422(15)00338-5. Epub 2015 Dec 19


Tuesday, February 13, 2018 - 12:30pm


Burke Medical Research Institute
785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

Conditions & Recovery

Stroke icon
Stroke is the leading cause of disability in the U.S.

Research Methods: