Metabolism

Impact

PUBLICATION:

Journal Article

Yun Yang, Victor Tapias, Diana Acosta, Hui Xu, Huanlian Chen, Ruchika Bhawal, Elizabeth T. Anderson, Elena Ivanova, Hening Lin, Botir T. Sagdullaev, Jianer Chen, William L. Klein, Kirsten L. Viola, Sam Gandy, Vahram Haroutunian, M. Flint Beal, David Eliezer, Sheng Zhang & Gary E. Gibson

Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease

Nat Commun. 2022 Jan 10;13(1):159. doi: 10.1038/s41467-021-27572-2.

Open Access on Nature

Gibson Lab

NEWS:

Article

June 4, 2021

Decades of Research Advancements Pave the Way to Slow Down Alzheimer’s Disease by Targeting Early-Onset

Today, scientists still do not know the cause of Alzheimer’s disease (AD), yet decades of research advancements give hope to the possibility of slowing down early-onset of AD. Benfotiamine, a therapeutic drug that raises blood vitamin B1, levels very high, was recently tested as a pilot clinical study conducted by the Gibson Lab at the Burke Neurological Institute.

Ratan Lab

NEWS:

Article

February 25, 2021

A First Time Study on Brain Tissue Identifies Key Cells that Facilitate Early Stages of Repair After Stroke

The research team examined how myeloid cells can also facilitate repair by clearing debris and promoting tissue remodeling during the early stages of repair. The study showed that a transcription factor, hypoxia-inducible factor, which the Ratan lab has been studying for years, marks myeloid cells that are associated with good long term recovery.

Ratan Lab

PUBLICATION:

Case Report

Michael H. Askenase, Brittany A. Goods, Hannah E. Beatty, Arthur F. Steinschneider, Sofia E. Velazquez, Artem Osherov, Margaret J. Landreneau, Shaina L. Carroll, Tho B. Tran, Victor S. Avram, Riley S. Drake, G. James Gatter, Jordan A. Massey, Saravanan S. Karuppagounder, Rajiv R. Ratan, Charles C. Matouk, Kevin N. Sheth, Wendy C. Ziai, Adrian R. Parry-Jones, Issam A. Awad, Mario Zuccarello, Richard E. Thompson, Jesse Dawson, Daniel F. Hanley, J. Christopher Love, Alex K. Shalek, Lauren H. Sansing, MISTIE III Consortium, ICHseq investigators

Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage

Science Immunology 2021 Feb 19;6(56):eabd6279. doi: 10.1126/sciimmunol.abd6279. Epub 2021 Feb 19.

Full-Text on PMC

Gibson Lab

NEWS:

In the Media

December 29, 2020

Benfotiamine and Cognitive Decline in Alzheimer's Disease Study Listed as a Top Non-Pandemic Advances in Health Care During 2020

Media Outlet:

CNN Health

Benfotiamine and Cognitive Decline in Alzheimer's Disease, a small exploratory clinical trial, conducted by Dr. Gary E. Gibson’s laboratory at the Burke Neurological Institute is listed in CNN Health’s article on ”Top 2020 health stories you may have missed because of Covid-19” under Advances in Alzheimer’s.

Gibson Lab

NEWS:

Article

November 25, 2020

New Data Suggests Raising Vitamin B1 Levels very high Helps People Living with mild Alzheimer’s Disease

A small exploratory clinical trial conducted by Dr. Gary E. Gibson’s laboratory at the Burke Neurological Institute in collaboration with physicians at the Burke Rehabilitation Hospital, suggests that Benfotiamine is safe and potentially efficacious in improving cognitive outcomes among people living with Mild Cognitive Impairment and mild Alzheimer’s disease (AD).

Gibson Lab

PUBLICATION:

Manuscript

Gary E Gibson, José A Luchsinger, Rosanna Cirio, Huanlian Chen, Jessica Franchino-Elder, Joseph A Hirsch, Lucien Bettendorff, Zhengming Chen, Sarah Flowers, Linda Gerber, Thomas Grandville, Nicole Schupf, Hui Xu, Yaakov Stern, Christian Habeck, Barry Jordan, Pasquale Fonzetti

Benfotiamine and Cognitive Decline in Alzheimer's Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial

J Alzheimers Dis. 2020;78(3):989-1010. doi: 10.3233/JAD-200896. Author manuscript; available in PMC 2021 Feb 12.

Full-Text on Pubmed

EVENT:

Weekly Seminar | Not Open to the Public

Oscillatory Mitochondrial Energy Sensing Via ADP Privation: From Mitochondrial GTP to Beta-Cell Therapy

Tuesday, November 19, 2019 - 12:30pm

Billings Building – Rosedale