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Metabolism

Impact

Gibson Lab
RESEARCH PROJECT: 
Complete
A Clinical Trial Testing Whether Glucose Metabolism Is an Effective Therapeutic Target in Alzheimer’s Disease
Thiamine (vitamin B1) dependent processes are reduced in Alzheimer’s disease. Thiamine deficiency mimics many aspects of Alzheimer’s disease including the reduced glucose metabolism and exaggeration of the plaque and tangle pathology.
Gibson Lab
PRESENTATION: 
Poster Presentation
July 16, 2017 to July 20, 2017
Glucose Metabolism as a Therapeutic Target in Alzheimer’s Disease
Venue: 
Alzheimer's Association International Conference, London, England
Featured Researchers: 
Gary E. Gibson, Ph.D.
Gibson Lab
PRESENTATION: 
Conference
July 16, 2017 to July 20, 2017
Metabolism, Oxidative Stress and Alzheimer’s Disease
Venue: 
Alzheimer's Association International Conference, London, England
Featured Researchers: 
Gary E. Gibson, Ph.D.
Gibson Lab
PUBLICATION: 
Journal Article
Chen H, Xu H, Potash S, Starkov A, Belousov VV, Bilan DS, Denton TT, Gibson GE.
Mild metabolic perturbations alter succinylation of mitochondrial proteins.
J Neurosci Res. 2017 Jun 20. doi: 10.1002/jnr.24103. [Epub ahead of print]
Abstract on PubMed
Gibson Lab
PUBLICATION: 
Review
Gibson GE, Thakkar A.
Mitochondria/metabolic reprogramming in the formation of neurons from peripheral cells: Cause or consequence and the implications to their utility.
Neurochem Int. 2017 Jun 13. pii: S0197-0186(17)30332-7. doi: 10.1016/j.neuint.2017.06.007. [Epub ahead of print]
Abstract on PubMed
Gibson Lab
PRESENTATION: 
Seminar
May 3, 2017
Glucose Metabolism as a Therapeutic Target in Alzheimer’s Disease
Venue: 
Montefiore Hudson Valley, Center of Excellence for Alzheimer’s Disease (CEAD), Bronx, NY
Featured Researchers: 
Gary E. Gibson, Ph.D.
Gibson Lab
PUBLICATION: 
Journal Article
Gibson GE, Thakkar A.
Interactions of Mitochondria/Metabolism and Calcium Regulation in Alzheimer's Disease: A Calcinist Point of View.
Neurochem Res. 2017 Jun;42(6):1636-1648. doi: 10.1007/s11064-017-2182-3. Epub 2017 Feb 8.
Abstract on PubMed
Gibson Lab
PUBLICATION: 
Journal Article
Naseri NN, Bonica J, Xu H, Park LC, Arjomand J, Chen Z, Gibson GE.
Novel Metabolic Abnormalities in the Tricarboxylic Acid Cycle in Peripheral Cells From Huntington's Disease Patients.
PLoS One. 2016 Sep 9;11(9):e0160384. doi: 10.1371/journal.pone.0160384.
Full-Text on PubMed
Gibson Lab
PUBLICATION: 
Journal Article
Chen H, Denton TT, Xu H, Calingasan N, Beal MF, Gibson GE.
Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?
J Neurochem. 2016 Dec;139(5):823-838. doi: 10.1111/jnc.13836.
Abstract on PubMed
Ratan Lab
GRANT: 
Federal
April 15, 2016 to March 31, 2021
Glucose Metabolism, Synaptic Plasticity, and Oxidative Stress in Alzheimer's Disease
Funding Status: 
Active Project
National Institutes of Health (NIH)
National Institute on Aging (NIA)
Grant Number: 
P01AG014930
Investigators: 
Rajiv R. Ratan, M.D., Ph.D.
Project Leader

Causes

Stroke, Cognitive Recovery, Neurodegenerative Diseases