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Metabolism

Impact

Gibson Lab
PUBLICATION: 
Journal Article
Santos SS, Gibson GE, Cooper AJ, Denton TT, Thompson CM, Bunik VI, Alves PM, Sonnewald U.
Inhibitors of the alpha-ketoglutarate dehydrogenase complex alter [1-13C]glucose and [U-13C]glutamate metabolism in cerebellar granule neurons.
J Neurosci Res. 2006 Feb 15;83(3):450-8.
Abstract on PubMed
Gibson Lab
PUBLICATION: 
Journal Article
Kim SY, Marekov L, Bubber P, Browne SE, Stavrovskaya I, Lee J, Steinert PM, Blass JP, Beal MF, Gibson GE, Cooper AJ.
Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain.
Neurochem Res. 2005 Oct;30(10):1245-55.
Abstract on PubMed
Gibson Lab
PUBLICATION: 
Journal Article
Ke ZJ, Calingasan NY, Karuppagounder SS, DeGiorgio LA, Volpe BT, Gibson GE.
CD40L deletion delays neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism.
J Neuroimmunol. 2005 Jul;164(1-2):85-92.
Abstract on PubMed
Gibson Lab
PUBLICATION: 
Journal Article
Ke ZJ, Calingasan NY, DeGiorgio LA, Volpe BT, Gibson GE.
CD40-CD40L interactions promote neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism.
Neurochem Int. 2005 Aug;47(3):204-15.
Abstract on PubMed
Gibson Lab
PUBLICATION: 
Journal Article
Shi Q, Chen HL, Xu H, Gibson GE.
Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity.
J Biol Chem. 2005 Mar 25;280(12):10888-96.
Abstract on PubMed
Gibson Lab
PUBLICATION: 
Journal Article
Bubber P, Ke ZJ, Gibson GE.
Tricarboxylic acid cycle enzymes following thiamine deficiency.
Neurochem Int. 2004 Dec;45(7):1021-8.
Abstract on PubMed
Gibson Lab
PUBLICATION: 
Review
Ke ZJ, Gibson GE.
Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism.
Neurochem Int. 2004 Jul-Aug;45(2-3):361-9. Review.
Abstract on PubMed
Gibson Lab
PUBLICATION: 
Review
Blass JP, Gibson GE, Hoyer S.
The role of the metabolic lesion in Alzheimer's disease.
J Alzheimers Dis. 2002 Jun;4(3):225-32. Review.
Abstract on PubMed
Gibson Lab
PUBLICATION: 
Journal Article
Gibson GE, Zhang H.
Abnormalities in oxidative processes in non-neuronal tissues from patients with Alzheimer's disease.
J Alzheimers Dis. 2001 Jun;3(3):329-338.
Abstract on PubMed
Gibson Lab
PUBLICATION: 
Review
Gibson GE.
Interactions of oxidative stress with cellular calcium dynamics and glucose metabolism in Alzheimer's disease.
Free Radic Biol Med. 2002 Jun 1;32(11):1061-70. Review.
Abstract on PubMed

Causes

Stroke, Cognitive Recovery, Neurodegenerative Diseases