You are here

Oscillatory Mitochondrial Energy Sensing Via ADP Privation: From Mitochondrial GTP to Beta-Cell Therapy

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Dr. Kibbey is a clinically-active physician scientist dedicated to the treatment of diabetes and other metabolic diseases. Mitochondria, as the primary sites of consumption and production of metabolites and energy, are central to regulation of insulin secretion and glucose production. Mitochondria, therefore, require mechanisms to ‘sense’ their own metabolic environment in order to efficiently respond to supply and demand termed ‘metabolic equilibrioception.’ He has developed a special expertise in measuring the flow of intermediary metabolism and built the LC/MS/MS method Mass Isotopomeric Multi-Ordinate Spectroscopic Analysis (MIMOSA) as a technique to resolve the complex and interwoven isotopomer patterns generated by mitochondrial metabolism. With this strength he is sought out in academia and industry as co-author or co-investigator in studies of diabetes as well as many other branches of metabolism. As such, he runs a YCC and DRC sponsored MIMOSA/metabolomics core, a spin-off company, and directs a graduate class in bioenergetics and metabolism.

Dr. Richard Kibbey's Figure


Alves TC, Pongratz RL, Zhao X, Yarborough O, Sereda S, Shirihai O, Cline GW, Mason G, Kibbey RG.
Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle.
Cell Metab. 2015 Nov 3;22(5):936-47. doi: 10.1016/j.cmet.2015.08.021. Epub 2015 Sep 24.
Jesinkey SR, Madiraju AK, Alves TC, Yarborough OH, Cardone RL, Zhao X, Parsaei Y, Nasiri AR, Butrico G, Liu X, Molina AJ, Rountree AM, Neal AS, Wolf DM, Sterpka J, Philbrick WM, Sweet IR, Shirihai OH, Kibbey RG.
Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos.
Cell Rep. 2019 Jul 16;28(3):759-772.e10. doi: 10.1016/j.celrep.2019.06.058.
Gassaway BM, Cardone RL, Padyana AK, Petersen MC, Judd E, Hayes S, Tong S, Barber KW, Apostolidi M, Abulizi A, Sheetz JB, Aerni HR, Kung C, Samuel VT, Shulman GI, Kibbey RG, Rinehart J
Distinct hepatic PKA and CDK signaling pathways control activity-independent pyruvate kinase phosphorylation and hepatic glucose production.
(2019) Cell Reports (in press)


Tuesday, November 19, 2019 - 12:30pm


785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

More Information

Lindsey Echevarria

Research Methods: