To Test Whether Changes in Metabolism and Calcium Regulation Seen in Animal Models or Peripheral Tissues form Alzheimer’s Disease Patients Occur in Human Neurons Derived from Inducible Pluripotent Stem Cells

Alzheimer’s disease related changes in releasable internal calcium stores as well as in mitochondrial function have been suggested from animal studies and cultured cells from Alzheimer’s disease patients such as fibroblasts, and make good therapeutic targets. However, they have never been studied in neurons from humans. In collaboration with the New York Stem Cell Foundation, we have established the methods to test whether the changes exist in human neurons and if they are good therapeutic targets. 

Neurons derived from iPSC