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Understanding the Multicellular Response to Injury in the Mouse Spinal Cord
Our lab studies the mechanisms of axon regeneration and sprouting after central nervous system (CNS) injury using mouse models of spinal cord injury. We started with the myelin-derived inhibitors and recently shifted focus to neuron-intrinsic pathways such as Pten/mTOR and MAP3Ks. We documented an age-dependent decline in axon regeneration and illustrated a multicellular role for the MAP3K12/13 pathway after CNS injury. Our in vivo imaging data supports a synaptic suppression hypothesis of axon regeneration.