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Understanding the Multicellular Response to Injury in the Mouse Spinal Cord
EVENT:
Weekly Seminar | Not Open to the PublicHost:
Who Should Attend:
ResearchersEvent Flyer:
seminar-binhai-zheng-111219.pdfSpeakers
Abstract
Our lab studies the mechanisms of axon regeneration and sprouting after central nervous system (CNS) injury using mouse models of spinal cord injury. We started with the myelin-derived inhibitors and recently shifted focus to neuron-intrinsic pathways such as Pten/mTOR and MAP3Ks. We documented an age-dependent decline in axon regeneration and illustrated a multicellular role for the MAP3K12/13 pathway after CNS injury. Our in vivo imaging data supports a synaptic suppression hypothesis of axon regeneration.
Publications
Neuron. 2015 May 20;86(4):947-954. doi: 10.1016/j.neuron.2015.03.061. Epub 2015 Apr 30.
Cell Rep. 2016 Apr 12;15(2):238-46. doi: 10.1016/j.celrep.2016.03.028. Epub 2016 Mar 31.
Cell Rep. 2018 Mar 27;22(13):3587-3597. doi: 10.1016/j.celrep.2018.02.102.
When
Tuesday, November 12, 2019 - 12:30pm
Where
785 Mamaroneck Avenue
White Plains, NY 10605
United StatesConference Room:
Billings Building – RosedaleMore Information
Lindsey Echevarria
Conditions & Recovery
Research Methods:
Axonal Regeneration