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Temporal Controls Over Cortical Neuron Diversity
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Weekly Seminar | Not Open to the PublicHost:
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seminar-030122-denis-jabaudon.pdfSpeakers
Research Statement
While the diversity of neurons in the adult mammalian brain is staggering, these cells emerge from a seemingly limited set of progenitors during development. This begs the question of how complexity emerges from a finite number of elements during dynamic biological processes. Here, I will discuss recent work from my laboratory addressing relationships between genetic diversity and connectivity in single-cell types, and how progenitor diversity may constrain adult brain cellular states during normal and abnormal brain development.
Publications
Nature. 2021 Nov;599(7885):453-457. doi: 10.1038/s41586-021-04048-3. Epub 2021 Nov 9.
Nature. 2019 Sep;573(7774):370-374. doi: 10.1038/s41586-019-1515-6. Epub 2019 Aug 28.
Science. 2019 May 10;364(6440):eaav2522. doi: 10.1126/science.aav2522.
Cell. 2018 Aug 23;174(5):1264-1276.e15. doi: 10.1016/j.cell.2018.06.036. Epub 2018 Jul 26.
Nature. 2016 Oct 6;538(7623):96-98. doi: 10.1038/nature19770. Epub 2016 Sep 26.
Science. 2016 Mar 25;351(6280):1443-6. doi: 10.1126/science.aad8361. Epub 2016 Mar 3.