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Temporal Controls Over Cortical Neuron Diversity

Weekly Seminar | Not Open to the Public
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Research Statement

While the diversity of neurons in the adult mammalian brain is staggering, these cells emerge from a seemingly limited set of progenitors during development. This begs the question of how complexity emerges from a finite number of elements during dynamic biological processes. Here, I will discuss recent work from my laboratory addressing relationships between genetic diversity and connectivity in single-cell types, and how progenitor diversity may constrain adult brain cellular states during normal and abnormal brain development.

Dr. Denis Jabaudon's Figure


Esther Klingler, Ugo Tomasello, Julien Prados, Justus M Kebschull, Alessandro Contestabile, Gregorio L Galiñanes, Sabine Fièvre, Antonio Santinha, Randal Platt, Daniel Huber, Alexandre Dayer, Camilla Bellone, Denis Jabaudon
Temporal controls over inter-areal cortical projection neuron fate diversity
Nature. 2021 Nov;599(7885):453-457. doi: 10.1038/s41586-021-04048-3. Epub 2021 Nov 9.
Polina Oberst, Sabine Fièvre, Natalia Baumann, Cristina Concetti, Giorgia Bartolini, Denis Jabaudon
Temporal plasticity of apical progenitors in the developing mouse neocortex
Nature. 2019 Sep;573(7774):370-374. doi: 10.1038/s41586-019-1515-6. Epub 2019 Aug 28.
L Telley, G Agirman, J Prados, N Amberg, S Fièvre, P Oberst, G Bartolini, I Vitali, C Cadilhac, S Hippenmeyer, L Nguyen, A Dayer, D Jabaudon
Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex
Science. 2019 May 10;364(6440):eaav2522. doi: 10.1126/science.aav2522.
Ilaria Vitali, Sabine Fièvre, Ludovic Telley, Polina Oberst, Sebastiano Bariselli, Laura Frangeul, Natalia Baumann, John J McMahon, Esther Klingler, Riccardo Bocchi, Jozsef Z Kiss, Camilla Bellone, Debra L Silver, Denis Jabaudon
Progenitor Hyperpolarization Regulates the Sequential Generation of Neuronal Subtypes in the Developing Neocortex
Cell. 2018 Aug 23;174(5):1264-1276.e15. doi: 10.1016/j.cell.2018.06.036. Epub 2018 Jul 26.
Laura Frangeul, Gabrielle Pouchelon, Ludovic Telley, Sandrine Lefort, Christian Luscher, Denis Jabaudon
A cross-modal genetic framework for the development and plasticity of sensory pathways
Nature. 2016 Oct 6;538(7623):96-98. doi: 10.1038/nature19770. Epub 2016 Sep 26.
Ludovic Telley, Subashika Govindan, Julien Prados, Isabelle Stevant, Serge Nef, Emmanouil Dermitzakis, Alexandre Dayer, Denis Jabaudon
Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex
Science. 2016 Mar 25;351(6280):1443-6. doi: 10.1126/science.aad8361. Epub 2016 Mar 3.


Tuesday, March 1, 2022 - 12:30pm


Conference Room: 
Online Webinar

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Darlene White

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