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Neuroinflammation in Post-Stroke Injury and Repair

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Inflammatory mechanisms have become a prime target for stroke therapy mainly based on animal studies which suggest that certain immune mediators have profound detrimental effects in the early stage of the disease process. Several of these mechanisms are turned on with sufficient delay after ischemia-onset to make them amenable to therapeutic intervention. Clinical proof-of concept trials have investigated the efficacy of different immunomodulatory approaches in stroke patients. More recently, clinical studies aiming at preventing T cell migration into the brain reported controversial findings regarding prevention of infarct growth in neuroimaging studies but yielded some promising results on clinical endpoints. The talk will focus on the lessons learned from recent experimental and clinical immunomodulatory trials for stroke with a particular emphasis on the open questions regarding the role of neuroinflammation in long-term recovery and neuronal plasticity after stroke.

Dr. Arthur Liesz's Figure


Stefan Roth, Jiayu Cao, Vikramjeet Singh, Steffen Tiedt, Gabriel Hundeshagen, Ting Li, Julia D Boehme, Dhruv Chauhan, Jie Zhu, Alessio Ricci, Oliver Gorka, Yaw Asare, Jun Yang, Mary S Lopez, Markus Rehberg, Dunja Bruder, Shengxiang Zhang, Olaf Groß, Martin Dichgans, Veit Hornung, Arthur Liesz
Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade
Immunity. 2021 Apr 13;54(4):648-659.e8. doi: 10.1016/j.immuni.2021.02.004. Epub 2021 Mar 4.
Steffanie Heindl, Alessio Ricci, Olga Carofiglio, Qihui Zhou, Thomas Arzberger, Nikolett Lenart, Nicolai Franzmeier, Tibor Hortobagyi, Peter T Nelson, Ann M Stowe, Adam Denes, Dieter Edbauer, Arthur Liesz
Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies
J Exp Med. 2021 Aug 2;218(8):e20202411. doi: 10.1084/jem.20202411. Epub 2021 May 26.
Alessio Vittorio Colombo, Rebecca Katie Sadler, Gemma Llovera, Vikramjeet Singh, Stefan Roth, Steffanie Heindl, Laura Sebastian Monasor, Aswin Verhoeven, Finn Peters, Samira Parhizkar, Frits Kamp, Mercedes Gomez de Aguero, Andrew J MacPherson, Edith Winkler, Jochen Herms, Corinne Benakis, Martin Dichgans, Harald Steiner, Martin Giera, Christian Haass, Sabina Tahirovic, Arthur Liesz
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
Elife. 2021 Apr 13;10:e59826. doi: 10.7554/eLife.59826.


Tuesday, July 13, 2021 - 12:30pm


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Darlene White

Conditions & Recovery

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Stroke is the leading cause of disability in the U.S.