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Motor and sensory adaptation in pediatric hemiplegia

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Jason B. Carmel, M.D., Ph.D.
Lab Director
Motor Recovery Laboratory
Burke Medical Research Institute
Assistant Professor of Neuroscience
Brain and Mind Research Institute
Weill Cornell Medicine
Director of Research
Blythedale Children’s Hospital

Skilled movement requires motor commands to move muscles and sensory feedback to gauge fidelity of actual movement with intended movement. Injury of the developing nervous system affects the motor and sensory pathways differently. In the motor system, injury to one cerebral hemisphere causes persistence of bilateral connections from the uninjured hemisphere. In contrast, there are few bilateral connections in the touch and proprioception system, which provides key sensory feedback. In addition, one common developmental brain injury (periventricular lesion) spares these sensory connections, while another (middle cerebral artery infarction) usually compromises these connections. Both types of injury usually affect the corticospinal system, the principal motor pathway for skilled movement. This lecture presents evidence from animal models and humans that identifying the sensory and motor connections spared by injury is critical to understanding hand function. It will also advance the hypothesis that this understanding can be used to target therapies to neural circuits. 

Jason B. Carmel, M.D., Ph.D. Figure


Gupta D, Barachant A, Gordon AM, Ferre C, Kuo HC, Carmel JB, Friel KM.
Effect of sensory and motor connectivity on hand function in pediatric hemiplegia.
Ann Neurol. 2017 Nov;82(5):766-780. doi: 10.1002/ana.25080. Epub 2017 Nov 1.
Carmel JB, Friel KM.
The right stimulation of the right circuits: Merging understanding of brain stimulation mechanisms and systems neuroscience for effective neuromodulation in children
Kirton, Gilbert, editors. Calgary, AB, Canada: Academic Press; 2016. Pediatric Brain Stimulation. 1st ed.; p.195-208.
Wen T, Lall S, Pagnota C, Markward J, Hill NJ, Ratnadurai-Giridharan S, Carmel JB.
Plasticity in One Hemisphere, Control from Two: Adaptation in Descending Motor Pathways after Unilateral Corticospinal Injury in Neonatal Rats.
Revision submitted.


Tuesday, March 13, 2018 - 12:30pm


Burke Medical Research Institute
785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

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