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Mechanotransduction in Hearing and Auditory Circuit Development

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Dr. Ulrich Mueller's Photo
Bloomberg Distinguished Professor of Neuroscience and Biology
Director of Developmental Neuroscience


Hair cells of the inner ear are the mechanosensory cells for the perception of sound. I will discuss recent advances in the characterization of the molecular components of the mechanotransduction machinery of hair cells and how mechanotransduction shapes hearing and auditory circuit development.

Dr. Ulrich Mueller's Figure


Shuohao Sun, Travis Babola, Gabriela Pregernig, Kathy S So, Matthew Nguyen, Shin-San M Su, Adam T Palermo, Dwight E Bergles, Joseph C Burns, Ulrich Müller
Hair Cell Mechanotransduction Regulates Spontaneous Activity and Spiral Ganglion Subtype Specification in the Auditory System
Cell. 2018 Aug 23;174(5):1247-1263.e15. doi: 10.1016/j.cell.2018.07.008. Epub 2018 Aug 2.
Christopher L Cunningham, Xufeng Qiu, Zizhen Wu, Bo Zhao, Guihong Peng, Ye-Hyun Kim, Amanda Lauer, Ulrich Müller
TMIE Defines Pore and Gating Properties of the Mechanotransduction Channel of Mammalian Cochlear Hair Cells
Neuron. 2020 Jul 8;107(1):126-143.e8. doi: 10.1016/j.neuron.2020.03.033. Epub 2020 Apr 27.
Xiaoping Liang, Xufeng Qiu, Gilman Dionne, Christopher L Cunningham, Michele L Pucak, Guihong Peng, Ye-Hyun Kim, Amanda Lauer, Lawrence Shapiro, Ulrich Müller
CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells
Neuron. 2021 Jul 7;109(13):2131-2149.e15. doi: 10.1016/j.neuron.2021.05.007. Epub 2021 Jun 5.


Tuesday, November 9, 2021 - 12:30pm


Conference Room: 
Online Webinar

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