Mechanotransduction in Hearing and Auditory Circuit Development

EVENT:

Weekly Seminar | Not Open to the Public

Host:

Vibhu Sahni, Ph.D.

Who Should Attend:

Researchers

Event Flyer:

seminar-110921-ulrich-mueller.pdf

Speakers

Ulrich Mueller, Ph.D.

Bloomberg Distinguished Professor of Neuroscience and Biology

Developmental Neuroscience

The Johns Hopkins School of Medicine

Director of Developmental Neuroscience

Developmental Neuroscience

The Johns Hopkins School of Medicine

Abstract

Hair cells of the inner ear are the mechanosensory cells for the perception of sound. I will discuss recent advances in the characterization of the molecular components of the mechanotransduction machinery of hair cells and how mechanotransduction shapes hearing and auditory circuit development.

Dr. Ulrich Mueller's Figure

Publications

Shuohao Sun, Travis Babola, Gabriela Pregernig, Kathy S So, Matthew Nguyen, Shin-San M Su, Adam T Palermo, Dwight E Bergles, Joseph C Burns, Ulrich Müller

Hair Cell Mechanotransduction Regulates Spontaneous Activity and Spiral Ganglion Subtype Specification in the Auditory System

Cell. 2018 Aug 23;174(5):1247-1263.e15. doi: 10.1016/j.cell.2018.07.008. Epub 2018 Aug 2.

Christopher L Cunningham, Xufeng Qiu, Zizhen Wu, Bo Zhao, Guihong Peng, Ye-Hyun Kim, Amanda Lauer, Ulrich Müller

TMIE Defines Pore and Gating Properties of the Mechanotransduction Channel of Mammalian Cochlear Hair Cells

Neuron. 2020 Jul 8;107(1):126-143.e8. doi: 10.1016/j.neuron.2020.03.033. Epub 2020 Apr 27.

Xiaoping Liang, Xufeng Qiu, Gilman Dionne, Christopher L Cunningham, Michele L Pucak, Guihong Peng, Ye-Hyun Kim, Amanda Lauer, Lawrence Shapiro, Ulrich Müller

CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells

Neuron. 2021 Jul 7;109(13):2131-2149.e15. doi: 10.1016/j.neuron.2021.05.007. Epub 2021 Jun 5.

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Mechanotransduction in Hearing and Auditory Circuit Development

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