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Genetic Control of Neural Circuit Formation in the Basal Ganglia: Implications for Childhood Neurological Disorders

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Kenneth Campbell, Ph.D.
Regional Professor, UC Department of Pediatrics
Divisions of Developmental Biology and Neurosurgery
Cincinnati Children’s Hospital Medical Center, Cincinnati, OH


Our lab studies the molecular genetic mechanisms that control region specific neuronal differentiation in the mammalian ventral telencephalon and the subsequent assembly into circuitry within the basal ganglia and related brain structures. I will present work examining the molecular mechanisms that control the balance between neural progenitor maintenance and neuronal differentiation in the lateral ganglionic eminence (LGE) which gives rise to neurons of the basal ganglia. In the second half of the talk, I will discuss our work on the mechanisms controlling subtype-specific generation of striatal projection neurons. Our research has implications for understanding potential circuit abnormalities in childhood neurological disorders such as ADHD.

Kenneth Campbell, Ph.D. Figure


Ehrman LA, Mu X, Waclaw RR, Yoshida Y, Vorhees CV, Klein WH, Campbell K.
The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse.
Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E4026-35. doi: 10.1073/pnas.1308275110. Epub 2013 Sep 30.
Waclaw RR, Ehrman LA, Merchan-Sala P, Kohli V, Nardini D, Campbell K.
Foxo1 is a downstream effector of Isl1 in direct pathway striatal projection neuron development within the embryonic mouse telencephalon.
Mol Cell Neurosci. 2017 Apr;80:44-51. doi: 10.1016/j.mcn.2017.02.003. Epub 2017 Feb 14.
Kuerbitz J, Arnett M, Ehrman S, Williams MT, Vorhees CV, Fisher SE, Garratt AN, Muglia LJ, Waclaw RR, Campbell K.
Loss of Intercalated Cells (ITCs) in the Mouse Amygdala of Tshz1 Mutants Correlates with Fear, Depression, and Social Interaction Phenotypes.
J Neurosci. 2018 Jan 31;38(5):1160-1177. doi: 10.1523/JNEUROSCI.1412-17.2017. Epub 2017 Dec 18.


Tuesday, April 2, 2019 - 12:30pm


785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

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