Events

You are here

Circuit Organization of Mouse Motor Cortex

EVENT: 
Weekly Seminar | Not Open to the Public
Who Should Attend: 
Researchers

Abstract 

How do we control our hand movements? Our lab aims to understand the circuit-level mechanisms in the mouse’s sensorimotor pathways controlling hand and forelimb movements. I’ll discuss two lines of investigation. One is a bottom-up approach to characterize the cell-type-specific connections of forelimb motor and somatosensory cortex neurons both locally and remotely, particularly in thalamus, where results are showing both shared and divergent connectivity patterns in cortico-thalamo-cortical circuits across areas. The other is a top-down ethological approach, aiming to characterize at high spatiotemporal resolution how mice move their hands and digits during natural feeding behaviors. Analysis of high-speed, close-up video is revealing the kinematic building-blocks of dexterous food-handling movements, including a prominent role of the thumbs and ultra-fast stereotyped maneuvers.

Dr. Shepherd's Figure

Publications

Naoki Yamawaki, Xiaojian Li, Laurie Lambot, Lynn Y Ren, Jelena Radulovic, Gordon M G Shepherd
Long-range inhibitory intersection of a retrosplenial thalamocortical circuit by apical tuft-targeting CA1 neurons
Nat Neurosci, 22 (4), 618-626 Apr 2019
John M Barrett, Martinna G Raineri Tapies, Gordon M G Shepherd
Manual dexterity of mice during food-handling involves the thumb and a set of fast basic movements
PLoS One, 15 (1), e0226774 2020 Jan 15 eCollection 2020
Guo K, Yamawaki N, Barrett JM, Tapies MGR, Shepherd GMG
Cortico-Thalamo-Cortical Circuits of Mouse Forelimb S1 Are Organized Primarily as Recurrent Loops
Journal of Neuroscience (In Press)

When

Tuesday, November 10, 2020 - 12:30pm

Where

Conference Room: 
Online Webinar

More Information

Darlene White

Conditions & Recovery

Motor Recovery Icon
Write and walk again.