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Central Nervous System Scarring and Repair

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Damage to the mammalian central nervous system often leads to persistent functional deficits. One important cause why these deficits become permanent is the establishment of a scar that blocks regeneration. This seminar will explore the questions of (1.) what the origin and function of scar tissue is and (2.) how the fibrotic scar component influences axonal regeneration and functional recovery after CNS injury. Evidence will be presented that (1.) a specific subpopulation of perivascular cells is the main source of stromal scar tissue following spinal cord injury. (2.) Pericyte-derived fibrotic cells participate in the wound closure and are crucial for the re-establishment of tissue integrity after injury but constitute the long-term persistent fibrotic scar core. (3.) Attenuation of pericyte-derived scarring improves axonal regeneration and functional recovery. (4.) Pericytes are a new therapeutic target for the treatment of CNS lesions.

Dr. Christian Göritz's Figure


David O Dias, Jannis Kalkitsas, Yildiz Kelahmetoglu, Cynthia P Estrada, Jemal Tatarishvili, Daniel Holl, Linda Jansson, Shervin Banitalebi, Mahmood Amiry-Moghaddam, Aurélie Ernst, Hagen B Huttner, Zaal Kokaia, Olle Lindvall, Lou Brundin, Jonas Frisén, Christian Göritz
Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions
Nat Commun. 2021 Sep 17;12(1):5501. doi: 10.1038/s41467-021-25585-5.
David Oliveira Dias, Hoseok Kim, Daniel Holl, Beata Werne Solnestam, Joakim Lundeberg, Marie Carlén, Christian Göritz, Jonas Frisén
Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury
Cell. 2018 Mar 22;173(1):153-165.e22. doi: 10.1016/j.cell.2018.02.004. Epub 2018 Mar 1.
Christian Göritz, David O Dias, Nikolay Tomilin, Mariano Barbacid, Oleg Shupliakov, Jonas Frisén
A pericyte origin of spinal cord scar tissue
Science. 2011 Jul 8;333(6039):238-42. doi: 10.1126/science.1203165.


Tuesday, October 19, 2021 - 12:30pm


Conference Room: 
Online Webinar

More Information

Darlene White

Conditions & Recovery

Spinal Cord Injury icon
Around the world, between 300,000 and 500,000 people are living with a SCI.

Research Methods: 
Axonal Regeneration