You are here

Aging-Dependent Immune Mediated Control of Axonal Regeneration and Recovery After Injury

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Simone Di Giovanni's Photo
Professor & Chair in Restorative Neuroscience
Head of the Division of Neuroscience & Neurology Consultant (Honorary)


I will talk about a novel aging-dependent mechanism that restricts axonal regeneration after injury. I will show that it involves the role of a specific subset of CD8 T cells in the control of the regenerative ability of sensory neurons. Next I will demonstrate that treatment with monoclonal antibodies that antagonise the recruitment of these immune cells can promote repair and recovery. Lastly, I will discuss the potential broader implications of this discovery beyond the peripheral immune system.

Simone Di Giovanni's Figure


Zhou L, Kong G, Palmisano I, Cencioni MT, Danzi M, De Virgiliis F, Chadwick JS, Greg Crawford2, Yu Z, De Winter F, Lemmon V,Bixby J, Puttagunta R, Verhaagen J, Pospori C, Lo Celso C, Strid J, Botto M, Di Giovanni S.
Aging causes neuronal regenerative decline via reversible CXCL13-dependent CXCR5/CD8 T cell-neuron communication
Science. Editing stage. IF: 47,7
Guiping Kong, Luming Zhou, Elisabeth Serger, Ilaria Palmisano, Francesco De Virgiliis, Thomas H Hutson, Eilidh Mclachlan, Anja Freiwald, Paolo La Montanara, Kirill Shkura, Radhika Puttagunta, Simone Di Giovanni
AMPK controls the axonal regenerative ability of dorsal root ganglia sensory neurons after spinal cord injury
Nat Metab. 2020 Sep;2(9):918-933. doi: 10.1038/s42255-020-0252-3. Epub 2020 Aug 10.
Ilaria Palmisano, Matt C Danzi, Thomas H Hutson, Luming Zhou, Eilidh McLachlan, Elisabeth Serger, Kirill Shkura, Prashant K Srivastava, Arnau Hervera, Nick O' Neill, Tong Liu, Hassen Dhrif, Zheng Wang, Miroslav Kubat, Stefan Wuchty, Matthias Merkenschlager, Liron Levi, Evan Elliott, John L Bixby, Vance P Lemmon, Simone Di Giovanni
Epigenomic signatures in dorsal root ganglia underlie differential transcriptional responses between regenerative versus non-regenerative axonal injury.
Nat Neurosci. 2019 Nov;22(11):1913-1924. doi: 10.1038/s41593-019-0490-4. Epub 2019 Oct 7.


Tuesday, November 23, 2021 - 12:30pm


Conference Room: 
Online Webinar

More Information

Darlene White

Conditions & Recovery

Traumatic Brain Injury icon
In the U.S., over 5.3 million adults and children live with TBI.

Research Methods: 
Axonal Regeneration