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Advancing Research In Rare Neurodegenerative Diseases: A Focus On Multiple System Atrophy

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Miriam Sklerov, M.D., M.Sc.
Assistant Professor of Neurology
Movement Disorders Center
University of North Carolina
UNC CurePSP Center of Care
University of North Carolina


Background and Purpose: Research in rare neurodegenerative diseases is often limited and difficult to undertake for many reasons. We will explore some of these challenges using multiple system atrophy as a model. Multiple system atrophy (MSA) is a devastating neurodegenerative condition that bears many similarities with Parkinson’s disease. Clinical trials in this disease have been historically limited despite the lack of effective available treatments.


  1. To provide an educational overview of multiple system atrophy (MSA)
  2. To discuss the importance of biomarkers in MSA research
  3. To explore the potential use of neuroimaging as a tool in MSA research

Methods: We will first learn about the pathophysiology and epidemiology of MSA to emphasize the importance of research in this disease. This will lead us to a discussion on the current obstacles we face in this area of research, as well as advances that may aid our endeavors.

Conclusions: Neuroimaging has provided a window into our knowledge of MSA and holds promise to become a useful marker of disease in this and other neurodegenerative conditions.

Miriam Sklerov, M.D., M.Sc. Figure


Sklerov M, Dayan E, Browner N.
Functional neuroimaging of the central autonomic network: recent developments and clinical implications.
Clin Auton Res. 2018 Nov 23. doi: 10.1007/s10286-018-0577-0.
Dayan E, Sklerov M, Browner N.
Disrupted hypothalamic functional connectivity in patients with PD and autonomic dysfunction.
Neurology. 2018 Jun 5;90(23):e2051-e2058. doi: 10.1212/WNL.0000000000005641. Epub 2018 May 4.
Sklerov M, Kang UJ, Liong C, Clark L, Marder K, Pauciulo M, Nichols WC, Chung WK, Honig LS, Cortes E, Vonsattel JP, Alcalay RN.
Frequency of GBA variants in autopsy-proven multiple system atrophy.
Mov Disord Clin Pract. 2017 Jul-Aug;4(4):574-581. doi: 10.1002/mdc3.12481. Epub 2017 Apr 3.


Tuesday, January 15, 2019 - 12:30pm


785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

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