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Converging integration between ascending proprioceptive inputs and the corticospinal tract motor circuit underlying skilled movement control

John Kalambogias, Yutaka Yoshida
Year Published: 
Curr Opin Physiol . 2021 Feb;19:187-193. doi: 10.1016/j.cophys.2020.10.007. Epub 2020 Nov 13.
PMID: 33718693 PMCID: PMC7949357 (available on 2022-02-01) DOI: 10.1016/j.cophys.2020.10.007
Abstract on PubMed


Converging interactions between ascending proprioceptive afferents and descending corticospinal tract projections are critical in the modulation and coordination of skilled motor behaviors. Fundamental to these processes are the functional inputs and the mechanisms of integration in the brain and spinal cord between proprioceptive and corticospinal tract information. In this review, we first highlight key connections between corticospinal tract motor circuit and spinal interneurons that receive proprioceptive inputs. We will also address corticospinal tract access to the presynaptic inhibitory system in the spinal cord and its role in modulating proprioceptive stimuli. Lastly, we will focus on the corticospinal neuron influences on the dorsal column nuclei complex, an integration hub for processing ascending somatosensory information.


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