Basic & Translational Research

We renew hope

Burke Neurological Institute brings hope to those living with neurological disabilities. In our research laboratories led by faculty, we translate groundbreaking basic and translational research into clinical treatments to help people can see, talk, and walk again.

Faculty & Research Labs

Preclinical Stroke Modeling Laboratory
We closely examine stroke pathology to address the gap between preclinical and clinical settings for translational medicine.
Laboratory for Patient Recruitment and Engagement
We aim is to understand and improve cancer treatment-related cognitive deficits.
Clinical Laboratory for Early Brain Injury Recovery
We aims to improve hand function in children with cerebral palsy (CP).
Laboratory for Mitochondrial Biology and Metabolic Dysfunction in Neurodegeneration
We aim to discover the underlying cause of age-related neurodegenerative diseases to develop effective therapies.
Circuit Repair Laboratory
We study the function of cortical motor networks after spinal cord injury.
Human Motor Recovery Laboratory
We are studying the control of movements after neurological injury, particularly after stroke.
Laboratory for Visual Disease and Therapy
We focus on advancing treatments for visual dysfunction and vision loss in adults and children.
Laboratory for Redox Biology and Neural Protection and Repair
We aim to understand adaptive programs that facilitate the brain's ability to combat injury and to foster repair.
Visual Plasticity and Repair Laboratory
We focuses on sensory signal processing, on how fundamental yet simple synaptic mechanisms underlie our perception of the world around us.
Laboratory for Cell Fate Specification and Circuit Development
We aim is to identify molecules that can be recruited to restore functions or to take on new functions.
Laboratory for Axonal and RNA Biology
We focus on sensory neuron axonal biology, on how local events within the axon are important in driving normal and pathological behaviors. 
Neural Connectivity Development in Physiology and Disease Laboratory
We are interested in formation, function, and regeneration of motor circuits controlling locomotor and skilled movements.
Molecular Regeneration and Neuroimaging Laboratory
We focus on elucidating the molecular mechanisms that drive axon regeneration during early development after injury or degenerative disease.

Core Facilities

Structural and Functional Imaging Core
Offers experimental and educational resources, data analysis and documentation to the investigators.
Spinal Cord Injury Core
Offers expertise on conducting spinal cord injury experiments and a facility with advanced equipment.