Hyperpolarized 13C MRS- Redox Imaging and the Brain

Abstract

The goal of research in the Wilson lab is to develop metabolism and microenvironment-targeted imaging methods, to guide intervention and predict response to molecular therapies. The lab develops cutting-edge magnetic resonance imaging (MRI) and positron emission tomography (PET) techniques to study basic biochemical pathways and their alterations in cancer and other metabolic disorders. New chemistries are used in the design and synthesis of imaging probes, which have strong potential for translation into the clinic. We are particularly focused on the molecular imaging of antioxidants and reactive oxygen species that play a crucial role in the development and progression of disease.