Translational and Transcriptional Control of ATF4

Abstract

Most of the research work in Dr. Qian's laboratory is broadly interdisciplinary, with a primary emphasis on mRNA translation, nutrient signaling pathway, and stress response. Using deep sequencing approach, the Qian laboratory investigates transcriptional and translational control of stress gene expression in mammals. We are also interested in deciphering RNA regulatory logic using massively paralleled reporter assay. More recently, we are exploring intracellular nutrient reprogramming and the implications in pathophysiology of human diseases.