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Translational and Transcriptional Control of ATF4

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Most of the research work in Dr. Qian's laboratory is broadly interdisciplinary, with a primary emphasis on mRNA translation, nutrient signaling pathway, and stress response. Using deep sequencing approach, the Qian laboratory investigates transcriptional and translational control of stress gene expression in mammals. We are also interested in deciphering RNA regulatory logic using massively paralleled reporter assay. More recently, we are exploring intracellular nutrient reprogramming and the implications in pathophysiology of human diseases.

Dr. Shu-Bing Qian's Figure


Xin Erica Shu, Yuanhui Mao, Longfei Jia, Shu-Bing Qian
Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress
Nat Chem Biol. 2022 Feb;18(2):134-141. doi: 10.1038/s41589-021-00913-4. Epub 2021 Dec 9.
Leiming Dong, Yuanhui Mao, Aidong Zhou, Xiao-Min Liu, Jun Zhou, Ji Wan, Shu-Bing Qian
Relaxed initiation pausing of ribosomes drives oncogenic translation
Sci Adv. 2021 Feb 17;7(8):eabd6927. doi: 10.1126/sciadv.abd6927. Print 2021 Feb.
Longfei Jia, Yuanhui Mao, Quanquan Ji, Devin Dersh, Jonathan W Yewdell, Shu-Bing Qian
Decoding mRNA translatability and stability from the 5' UTR
Nat Struct Mol Biol. 2020 Sep;27(9):814-821. doi: 10.1038/s41594-020-0465-x. Epub 2020 Jul 27.


Tuesday, October 4, 2022 - 12:30pm


Conference Room: 
Billings Building – Rosedale & Zoom

More Information

Darlene White

Research Methods: 
Gene Expression, Genetics