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Traffic Jams and Brain Development: Exploring Links Between Neural Development and Disease

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Anthony P. Barnes, Ph.D.
Assistant Professor of Medicine
Division of Cardiovascular Medicine School of Medicine, Program in Molecular and Cellular Biosciences School of Medicine
Oregon Health and Science University


The developing brain is characterized by rapid and persistent remodeling. Neural progenitors and their progeny respond to changing molecular landscapes by adapting their complement of cell surface membrane proteins through highly ordered and regulated mechanisms of plasma membrane insertion, followed by later endocytosis and degradation. While these pathways have been implicated in the neuronal compromise associated with neurodegeneration and injury, little is known about their contribution to proper brain development. We have addressed this question through a multidisciplinary approach that incorporates mouse genetics, magnetic resonance and electron microscopy and biochemistry. Our results indicate that compromised endolysosomal trafficking leads to perturbations of progenitor proliferation, axon pathfinding and cell migration in the embryonic cerebral cortex.

Anthony P. Barnes, Ph.D. Figure


Nelson JW, Ferdaus MZ, McCormick JA, Minnier J, Kaul S, Ellison DH, Barnes AP.
Endothelial transcriptomics reveals activation of fibrosis-related pathways in hypertension.
Physiol Genomics. 2018 Feb 1;50(2):104-116. doi: 10.1152/physiolgenomics.00111.2017. Epub 2018 Jan 8.
Veleva-Rotse BO, Smart JL, Baas AF, Edmonds B, Zhao ZM, Brown A, Klug LR, Hansen K, Reilly G, Gardner AP, Subbiah K, Gaucher EA, Clevers H, Barnes AP.
STRAD pseudokinases regulate axogenesis and LKB1 stability.
Neural Dev. 2014 Mar 4;9:5. doi: 10.1186/1749-8104-9-5.
Veleva-Rotse BO, Barnes AP.
Brain patterning perturbations following PTEN loss.
Front Mol Neurosci. 2014 May 14;7:35. doi: 10.3389/fnmol.2014.00035. eCollection 2014.


Tuesday, June 19, 2018 - 12:30pm


785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

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