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Timing, Training, & Tinctures – Reorganization & Recovery After Stroke

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Steven R. Zeiler, M.D., Ph.D.
Assistant Professor
Department of Neurology, Cerebrovascular Division
Director Vascular Neurology Fellowship
Department of Neurology
Head of Stroke Research
Johns Hopkins Bayview Medical Center
Johns Hopkins, Baltimore, MD


Studies in humans and nonhuman animal models show that most recovery from impairment occurs in the first 1–3 months after stroke as a result of both spontaneous reorganization and increased responsiveness to enriched environments and training. Improvement from impairment is attributable to a short-lived sensitive period of postischemic plasticity defined by unique genetic, molecular, physiological, and structural events. Data suggests that there are hree important variables that determine the degree of motor recovery from impairment all else being equal: (i) the timing, intensity, and approach to training with respect to stroke onset, (ii) the unique post-ischemic plasticity milieu, and (iii) The extent of cortical reorganization. I will present data regarding both the biology of the brain’s post-stroke sensitive period and the difficult question of what kind of interventions best exploit this period. I will describe limitations of current post-stroke rehabilitation methods and suggest novel nterventions, which incorporate robotics, video-gaming, and pharmacological interventions including SSRIs and Cerebrolysin. Of import, Cerebrolysin has allowed us for the first time to model spontaneous recovery in an animal model of motor stroke.

Steven R. Zeiler, M.D., Ph.D. Figure


Zeiler SR, Hubbard R, Gibson EM, Zheng T, Ng K, O'Brien R, Krakauer JW.
Paradoxical Motor Recovery From a First Stroke After Induction of a Second Stroke: Reopening a Postischemic Sensitive Period.
Neurorehabil Neural Repair. 2016 Sep;30(8):794-800. doi: 10.1177/1545968315624783. Epub 2015 Dec 31.
Zeiler SR, Krakauer JW.
The interaction between training and plasticity in the poststroke brain.
Curr Opin Neurol. 2013 Dec;26(6):609-16. doi: 10.1097/WCO.0000000000000025.
Ng KL, Gibson EM, Hubbard R, Yang J, Caffo B, O'Brien RJ, Krakauer JW, Zeiler SR.
Fluoxetine Maintains a State of Heightened Responsiveness to Motor Training Early After Stroke in a Mouse Model.
Stroke. 2015 Oct;46(10):2951-60. doi: 10.1161/STROKEAHA.115.010471. Epub 2015 Aug 20.


Tuesday, March 6, 2018 - 12:30pm


Burke Medical Research Institute
785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

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