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Stem Cell Transplant for Stroke: A 25 year journey from preclinical discovery to clinical translation

EVENT: 
Weekly Seminar | Not Open to the Public
Who Should Attend: 
Researchers
Event Flyer: 
PDF icon steinberg_11-5-24.pdf

Speakers

Speaker headshot
Bernard and Ronni Lacroute-William Randolph Hearst Professor of Neurosurgery and the Neurosciences Founder and Co-Director, Stanford Stroke Center Former Chair (1995-2020)
Department of Neurosurgery
Stanford University School of Medicine

Abstract

Except for vagal nerve stimulation, no treatment exists to restore function in chronic stroke patients. NR1 is a human embryonic derived neural stem cell that improved motor-sensory function in rodent stroke models, and was expanded to produce GMP cryopreserved cell lots. In this First-in-human Phase 1/2a Study, the safety & efficacy of NR1 intracerebral transplantation in chronic stroke patients was assessed over 12 months. All 18 transplanted subjects demonstrated improved total FMMS and 11/17 with ≥ 3 mos f/u showed clinically meaningful recovery. At 12 mos, subjects increased 12.1 points for total FMMS, 7.4 points for UE FMMS, 4.7 points for LE FMMS, 7.7 points for Barthel Index, while NIHSS improved by 1.77 and gait speed improved substantially. fMRI revealed improved brain connectivity and FDG PET showed increased activity. Intraparenchymal transplantation of NR1 cells in chronic stroke patients appears safe and well tolerated. Results suggest improved motor function starting at 1 mos and increasing to clinically meaningful recovery in most patients at 12 mos post-implant.

 Abstract Figure

Publications

Azevedo-Pereira RL, Manley NC, Dong C, Zhang Y, Lee A, Vu J, Berry JE, Bliss TM, Steinberg GK
Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain
Cell Reports, 2023; 42(4):112353.
Steinberg, G. K., Kondziolka, D., Wechsler, L. R., Lunsford, L. D., Coburn, M. L., Billigen, J. B., Kim, A. S., Johnson, J. N., Bates, D., King, B., Case, C., McGrogan, M., Yankee, E. W., Schwartz, N. E.
Clinical Outcomes of Transplanted Modified Bone Marrow-Derived Mesenchymal Stem Cells in Stroke A Phase 1/2a Study
Stroke. 2016;47(7):1817-24.
Andres RH, Horie N, Slikker W, Keren-Gill H, Zhan K, Sun G, Manley NC, Pereira MP, Sheikh LA, McMillan EL, Schaar BT, Svendsen CN, Bliss TM, Steinberg GK
Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain.
Brain. 2011;134(Pt 6):1777-89.

When

Tuesday, November 5, 2024 - 12:30pm

Where

Conference Room: 
Billings Building – Rosedale

More Information

Darlene White