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Stem Cell Biology and Transcriptomics of Human White Matter Diseases

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Dr. David Rowitch's Photo
Professor and Head of Department of Paediatrics
Wellcome Trust Senior Investigator
Hon. Consultant Paediatrician
Clinical Director of Studies
Adjunct Professor of Pediatrics


Multiple sclerosis (MS) is a common, debilitating, progressive and fatal neurological disease that targets myelinating oligodendrocytes. Although most likely driven by an autoimmune response, the effector mechanisms that cause inflammation and that lead to neurodegeneration are incompletely understood. Treatment options are limited and do not prevent the progressive phase. This talk will cover molecular, temporal and cellular diversity of glial cells in CNS development, and apply this perspective to understand what goes wrong in MS disease progression that: (1) causes inflammation in the brain, (2) death of neurons and brain shrinkage and (3) how to potentially enhance repair of lesions. In an effort to find biomarkers of disease progression and targets for new therapies, we have used transcriptomic approaches, stem cell models of oligodendrocyte disease that have highlighted a role for iron toxicity in cells of the oligodendrocyte lineage.

Dr. David Rowitch's Diagram


Lucas Schirmer, Dorothy P Schafer, Theresa Bartels, David H Rowitch, Peter A Calabresi
Diversity and Function of Glial Cell Types in Multiple Sclerosis
Trends Immunol. 2021 Mar;42(3):228-247. doi: 10.1016/ Epub 2021 Feb 13.
Omer Ali Bayraktar, Theresa Bartels, Staffan Holmqvist, Vitalii Kleshchevnikov, Araks Martirosyan, Damon Polioudakis, Lucile Ben Haim, Adam M H Young, Mykhailo Y Batiuk, Kirti Prakash, Alexander Brown, Kenny Roberts, Mercedes F Paredes, Riki Kawaguchi, John H Stockley, Khalida Sabeur, Sandra M Chang, Eric Huang, Peter Hutchinson, Erik M Ullian, Martin Hemberg, Giovanni Coppola, Matthew G Holt, Daniel H Geschwind, David H Rowitch
Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map
Nat Neurosci . 2020 Apr;23(4):500-509. doi: 10.1038/s41593-020-0602-1. Epub 2020 Mar 16.
Lucas Schirmer, Dmitry Velmeshev, Staffan Holmqvist, Max Kaufmann, Sebastian Werneburg, Diane Jung, Stephanie Vistnes, John H Stockley, Adam Young, Maike Steindel, Brian Tung, Nitasha Goyal, Aparna Bhaduri, Simone Mayer, Jan Broder Engler, Omer A Bayraktar, Robin J M Franklin, Maximilian Haeussler, Richard Reynolds, Dorothy P Schafer, Manuel A Friese, Lawrence R Shiow, Arnold R Kriegstein, David H Rowitch
Neuronal vulnerability and multilineage diversity in multiple sclerosis
Nature. 2019 Sep;573(7772):75-82. doi: 10.1038/s41586-019-1404-z. Epub 2019 Jul 17.


Tuesday, September 20, 2022 - 12:30pm


Conference Room: 
Billings Building – Rosedale & Zoom

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Darlene White

Conditions & Recovery

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