You are here

Resolvins in Inflammation and Infections

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Dr. Charles Serhan's Photo
Director Center for Experimental Therapeutics and Reperfusion Injury
Simon Gelman Professor


Uncontrolled Inflammation is considered as an integral component today of many diseases e.g., arthritis, periodontal disease, asthma, cardiovascular diseases and neurodegenerative diseases as well as poor nutrition and aging. To map tissue and molecular events in the resolution phase of self-limited inflammation, we’ve used a systematic approach interrogating exudates, cell traffic and identification of novel chemical mediators. In resolving exudates, we’ve identified 3 separate structurally distinct families of potent endogenous mediators named resolvins, protectins and maresins (macrophage mediators in resolving inflammation). These families are collectively coined specialized pro-resolving mediators (SPM) and are biosynthesized from essential fatty acid precursors. We’ve established the complete structures of the SPM, their biosynthesis and total organic synthesis focusing on defining their potent and novel functions in vivo animal disease models. Each member of the SPM superfamily is a proresolving mediator possessing potent multi-pronged anti-inflammatory, anti-microbial actions as well as stimulate tissue regeneration. Mapping of these resolution circuits has provided new avenues to probe the molecular basis of many diseases (for general over views see CN Serhan & BD Levy JCI 2018; CN Serhan, Nature 2014). This presentation will focus on our recent advances on SPM biosynthesis and functions in the regulation of inflammation in human model systems and mouse DVT. We operationalized LC-MS-MS based mediator metabololipidomics to profile SPM in tissues. These findings indicate that failed endogenous resolution pathways may underlie uncontrolled inflammation in human disease and opens the potential for resolution-based physiology and pharmacology.

Dr. Charles Serhan's Figure


Nan Chiang, Charles N Serhan
Specialized pro-resolving mediator network: an update on production and actions
Essays Biochem. 2020 Sep 23;64(3):443-462. doi: 10.1042/EBC20200018.
Charles N Serhan, Shailendra K Gupta, Mauro Perretti, Catherine Godson, Eoin Brennan, Yongsheng Li, Oliver Soehnlein, Takao Shimizu, Oliver Werz, Valerio Chiurchiù, Angelo Azzi, Marc Dubourdeau, Suchi Smita Gupta, Patrick Schopohl, Matti Hoch, Dragana Gjorgevikj, Faiz M Khan, David Brauer, Anurag Tripathi, Konstantin Cesnulevicius, David Lescheid, Myron Schultz, Eva Särndahl, Dirk Repsilber, Robert Kruse, Angelo Sala, Jesper Z Haeggström, Bruce D Levy, János G Filep, Olaf Wolkenhauer
The Atlas of Inflammation Resolution (AIR)
Mol Aspects Med. 2020 Aug;74:100894. doi: 10.1016/j.mam.2020.100894. Epub 2020 Sep 3.
Nan Chiang, Stephania Libreros, Paul C Norris, Xavier de la Rosa, Charles N Serhan
Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions
J Clin Invest. 2019 Dec 2;129(12):5294-5311. doi: 10.1172/JCI129448.


Tuesday, February 16, 2021 - 12:30pm


Conference Room: 
Online Webinar

More Information

Darlene White

Conditions & Recovery

Neurodegenerative Diseases icon
Worldwide, 50 million people are living with Alzheimer's and other dementias.

Research Methods: 
In Vivo Imaging