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Repressing Neurogenic Competence in Glia of the Retina and Brain

Weekly Seminar | Not Open to the Public
Who Should Attend: 


My group uses comparative single-cell multiomic analysis to identify gene regulatory networks that control neurogenesis and cell fate specification in developing retina and hypothalamus, as well as those that control neurogenic competence in retinal and hypothalamic glial cells. By integrating these findings, we aim to develop methods of replacing photoreceptors lost due to hereditary retinal dystrophies and of therapeutically modifying hypothalamic neural circuits that control essential physiological processes. I will focus on our group’s recent work on negative regulation of neurogenic competence in glial cells in the retina and brain.

Dr. Seth Blackshaw's Diagram


Brian S Clark, Genevieve L Stein-O'Brien, Fion Shiau, Gabrielle H Cannon, Emily Davis-Marcisak, Thomas Sherman, Clayton P Santiago, Thanh V Hoang, Fatemeh Rajaii, Rebecca E James-Esposito, Richard M Gronostajski, Elana J Fertig, Loyal A Goff, Seth Blackshaw
Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification
Neuron. 2019 Jun 19;102(6):1111-1126.e5. doi: 10.1016/j.neuron.2019.04.010. Epub 2019 May 22.
Thanh Hoang, Jie Wang, Patrick Boyd, Fang Wang, Clayton Santiago, Lizhi Jiang, Sooyeon Yoo, Manuela Lahne, Levi J Todd, Meng Jia, Cristian Saez, Casey Keuthan, Isabella Palazzo, Natalie Squires, Warren A Campbell, Fatemeh Rajaii, Trisha Parayil, Vickie Trinh, Dong Won Kim, Guohua Wang, Leah J Campbell, John Ash, Andy J Fischer, David R Hyde, Jiang Qian, Seth Blackshaw
Gene regulatory networks controlling vertebrate retinal regeneration
Science. 2020 Nov 20;370(6519):eabb8598. doi: 10.1126/science.abb8598. Epub 2020 Oct 1.
Pin Lyu, Thanh Hoang, Clayton P Santiago, Eric D Thomas, Andrew E Timms, Haley Appel, Megan Gimmen, Nguyet Le, Lizhi Jiang, Dong Won Kim, Siqi Chen, David F Espinoza, Ariel E Telger, Kurt Weir, Brian S Clark, Timothy J Cherry, Jiang Qian, Seth Blackshaw
Gene regulatory networks controlling temporal patterning, neurogenesis, and cell-fate specification in mammalian retina
Cell Rep. 2021 Nov 16;37(7):109994. doi: 10.1016/j.celrep.2021.109994.


Tuesday, October 18, 2022 - 12:30pm


Conference Room: 
Billings Building – Rosedale & Zoom

More Information

Darlene White

Conditions & Recovery

Neurodegenerative Diseases icon
Worldwide, 50 million people are living with Alzheimer's and other dementias.

Research Methods: 
Gene Expression