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Rehab-Induced Modulation of the Nociceptor After Spinal Cord Injury

Weekly Seminar | Not Open to the Public
Who Should Attend: 


My research is focused on understanding the molecular underpinnings that contribute to the development of chronic, debilitating neuropathic pain after spinal cord injury. This pain can be described as the pain of everyday living. Normal activities like wearing a t-shirt or testing the temperature of bath water are perceived as painful. There are two active lines of research ongoing in the lab.

1. Neuroimmune interactions associated with pain development after injury. Traumatic injury to the spinal cord induces a robust immune and inflammatory response at the site of primary injury. Recent evidence from our lab and others suggests that these responses are not limited to the site of injury, but rather extend to remote regions of the spinal cord, brain and dorsal root ganglia. We are focused on understanding how a specific type of immune cells called macrophages interact with pain-sensing neurons after injury to result in their dysfunction.

2. Rehabilitative strategies to prevent or reduce chronic neuropathic pain after injury. Physical therapy and rehabilitation is the standard of care for individuals who have sustained a spinal cord injury. In the lab, we use animal models of both injury and rehabilitation to understand how aerobic, resistance or range-of-motion exercises can induce plasticity or alterations in the anatomical and functional properties of pain sensing neurons.


Detloff MR, Smith EJ, Quiros Molina D, Ganzer PD, Houlé JD.
Acute exercise prevents the development of neuropathic pain and the sprouting of non-peptidergic (GDNF- and artemin-responsive) c-fibers after spinal cord injury.
Exp Neurol. 2014 May;255:38-48. doi: 10.1016/j.expneurol.2014.02.013. Epub 2014 Feb 19.
Detloff MR, Quiros-Molina D, Javia AS, Daggubati L, Nehlsen AD, Naqvi A, Ninan V, Vannix KN, McMullen MK, Amin S, Ganzer PD, Houlé JD.
Delayed Exercise Is Ineffective at Reversing Aberrant Nociceptive Afferent Plasticity or Neuropathic Pain After Spinal Cord Injury in Rats.
Neurorehabil Neural Repair. 2016 Aug;30(7):685-700. doi: 10.1177/1545968315619698. Epub 2015 Dec 14.
Chhaya SJ, Quiros-Molina D, Tamashiro-Orrego AD, Houlé JD, Detloff MR.
Exercise-Induced Changes to the Macrophage Response in the Dorsal Root Ganglia Prevent Neuropathic Pain after Spinal Cord Injury.
J Neurotrauma. 2019 Mar 19;36(6):877-890. doi: 10.1089/neu.2018.5819. Epub 2018 Oct 18.
Chhaya SJ, Schmidt KA, Gistzer SF, Detloff MR
Diverse immune response in the dorsal root ganglia acutely after spinal cord injury.
Scientific Reports - Under Revision


Tuesday, February 11, 2020 - 12:30pm


785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

More Information

Lindsey Echevarria

Conditions & Recovery

Spinal Cord Injury icon
Around the world, between 300,000 and 500,000 people are living with a SCI.