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PTEN, MIR, ROS and NSC: Studies of Acronyms in Autism

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Harley Kornblum M.D., Ph.D.
Departments of Psychiatry, Pharmacology and Pediatrics
David Geffen School of Medicine at UCLA
Associate Director
Semel Institute for Neuroscience and Human Behavior
UCLA Intellectual and Developmental Disabilities Research Center


The loss of Pten function results in macrocephaly and autism. We have been exploring the role of Pten in the genesis of normal neural stem cells. Genetic deletion or inactivation of Pten via reactive oxygen species can produce enhanced neural stem cell production. In the developing mouse fetus, maternal inflammation activates NADPH oxidase, which then activates reactive oxygen species, producing enlarged brains and many behavioral phenotypes similar to those found in autistic individuals. Surprisingly, we find that many of these behaviors can be temporarily reversed by pharmacologic treatment.

Harley Kornblum M.D., Ph.D. Figure


Groszer M, Erickson R, Scripture-Adams DD, Lesche R, Trumpp A, Zack JA, Kornblum HI, Liu X, Wu H.
Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.
Science. 2001 Dec 7;294(5549):2186-9. Epub 2001 Nov 1.
Le Belle JE, Orozco NM, Paucar AA, Saxe JP, Mottahedeh J, Pyle AD, Wu H, Kornblum HI.
Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner.
Cell Stem Cell. 2011 Jan 7;8(1):59-71. doi: 10.1016/j.stem.2010.11.028.
Le Belle JE, Sperry J, Ngo A, Ghochani Y, Laks DR, López-Aranda M, Silva AJ, Kornblum HI.
Maternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells.
Stem Cell Reports. 2014 Nov 11;3(5):725-34. doi: 10.1016/j.stemcr.2014.09.004. Epub 2014 Oct 11.


Tuesday, September 4, 2018 - 12:30pm


785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

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