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Phox2a Unravels a Developmental and Functional Logic of the Anterolateral System

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Anterolateral system neurons relay pain, itch, and temperature information from the spinal cord to pain related brain regions, but the differentiation of these neurons and their specific contribution to pain perception remain poorly defined. I will provide evidence that mouse spinal neurons that embryonically express the autonomic-system-associated Paired-like homeobox 2A (Phox2a) transcription factor innervate nociceptive brain targets, including the parabrachial nucleus and the thalamus. I will discuss the essential role for Phox2a in the development of relay of nociceptive signals from the spinal cord to the brain and how the molecular identity of Phox2a neurons is conserved in the human fetal spinal cord. I will also discuss the general logic of nociception in terms of homeostasis.

Dr. Artur Kania's Figure


R Brian Roome, Farin B Bourojeni, Bishakha Mona, Shima Rastegar-Pouyani, Raphael Blain, Annie Dumouchel, Charleen Salesse, W Scott Thompson, Megan Brookbank, Yorick Gitton, Lino Tessarollo, Martyn Goulding, Jane E Johnson, Marie Kmita, Alain Chédotal, Artur Kania
Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and Humans
Cell Rep. 2020 Nov 24;33(8):108425. doi: 10.1016/j.celrep.2020.108425.
Wafa A A Alsulaiman, Raphaelle Quillet, Andrew M Bell, Allen C Dickie, Erika Polgár, Kieran A Boyle, Masahiko Watanabe, R Brian Roome, Artur Kania, Andrew J Todd, Maria Gutierrez-Mecinas
Characterisation of lamina I anterolateral system neurons that express Cre in a Phox2a-Cre mouse line
Sci Rep. 2021 Sep 9;11(1):17912. doi: 10.1038/s41598-021-97105-w.
R Brian Roome, Shima Rastegar-Pouyani, Amy Ker, Annie Dumouchel, Marie Kmita, Artur Kania
Netrin1 and reelin signaling are required for the migration of anterolateral system neurons in the embryonic spinal cord
Pain. 2022 Apr 1;163(4):e527-e539. doi: 10.1097/j.pain.0000000000002444.


Tuesday, April 19, 2022 - 12:30pm


Conference Room: 
Billings Building – Rosedale and via Zoom Meeting

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Darlene White

Conditions & Recovery

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Pain free, touch and smell like before.