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Neurotechnologies to Restore Functions for Spinal Cord Injury

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Grégoire Courtine's Photo
Professor of Neuroscience and Neurotechnology
Professor of Neuroscience and Neurotechnology
Neurosurgery Department
Professor of Neuroscience and Neurotechnology
Faculty of Medicine and Biology


Over the past 15 years, my research team have developed a multipronged intervention that reestablished voluntary control of paralyzed legs in animal models of spinal cord injury, and recently in humans. This intervention acts over two time-windows. Immediately, electrical and chemical stimulations applied to the lumbar spinal cord reactivate lumbar executive centers located below the injury that coordinate leg movements, enabling voluntary control of paralyzed muscles. In the long term, will-powered training regimens enabled by these electrochemical stimulations and cutting-edge robotic assistance promote the reorganization of residual connections that restores voluntary movements without stimulation. We recently exploited these neurotechnologies to target the sympathetic circuitry, which allowed us to develop a neuroprosthetic baroreflex that precisely controls hemodynamic instability after SCI in preclinical models and humans. During my talk, I will discuss the technological and conceptual development underlying these interventions in preclinical models, how we translated these developments in humans with SCI, and how we envision the next steps to establish a clinically viable treatment.

Grégoire Courtine's Figure


Fabien B Wagner, Jean-Baptiste Mignardot, Camille G Le Goff-Mignardot, Robin Demesmaeker, Salif Komi, Marco Capogrosso, Andreas Rowald, Ismael Seáñez, Miroslav Caban, Elvira Pirondini, Molywan Vat, Laura A McCracken, Roman Heimgartner, Isabelle Fodor, Anne Watrin, Perrine Seguin, Edoardo Paoles, Katrien Van Den Keybus, Grégoire Eberle, Brigitte Schurch, Etienne Pralong, Fabio Becce, John Prior, Nicholas Buse, Rik Buschman, Esra Neufeld, Niels Kuster, Stefano Carda, Joachim von Zitzewitz, Vincent Delattre, Tim Denison, Hendrik Lambert, Karen Minassian, Jocelyne Bloch, Grégoire Courtine
Targeted neurotechnology restores walking in humans with spinal cord injury
Nature . 2018 Nov;563(7729):65-71. doi: 10.1038/s41586-018-0649-2. Epub 2018 Oct 31.
Leonie Asboth, Lucia Friedli, Janine Beauparlant, Cristina Martinez-Gonzalez, Selin Anil, Elodie Rey, Laetitia Baud, Galyna Pidpruzhnykova, Mark A Anderson, Polina Shkorbatova, Laura Batti, Stephane Pagès, Julie Kreider, Bernard L Schneider, Quentin Barraud, Gregoire Courtine
Cortico-reticulo-spinal circuit reorganization enables functional recovery after severe spinal cord contusion
Nat Neurosci . 2018 Apr;21(4):576-588. doi: 10.1038/s41593-018-0093-5. Epub 2018 Mar 19.
Marco Capogrosso, Tomislav Milekovic, David Borton, Fabien Wagner, Eduardo Martin Moraud, Jean-Baptiste Mignardot, Nicolas Buse, Jerome Gandar, Quentin Barraud, David Xing, Elodie Rey, Simone Duis, Yang Jianzhong, Wai Kin D Ko, Qin Li, Peter Detemple, Tim Denison, Silvestro Micera, Erwan Bezard, Jocelyne Bloch, Grégoire Courtine
A brain-spine interface alleviating gait deficits after spinal cord injury in primates
Nature . 2016 Nov 10;539(7628):284-288. doi: 10.1038/nature20118.


Tuesday, November 24, 2020 - 12:30pm


Conference Room: 
Online Webinar

More Information

Darlene White

Conditions & Recovery

Spinal Cord Injury icon
Around the world, between 300,000 and 500,000 people are living with a SCI.