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Neuroplasticity of Spinal Interneurons after Cervical Spinal Cord Injury

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Impaired breathing is a devastating consequence of cervical spinal cord injury (SCI), representing a significant burden to injured people and increasing the risk of mortality. Respiratory dysfunction and associated secondary complications remain the leading cause of morbidity and mortality in people with cervical SCI. Particularly concerning are reports indicating that the number of cervical SCIs has increased in recent years. While there is mounting clinical and experimental evidence for spontaneous improvements in respiration, the extent of recovery – or functional plasticity – remains incomplete. However, plasticity is reliant on spared neural substrates after incomplete spinal cord injury (SCI). Thus, the extent of recovery without therapeutic intervention and anatomical repair is limited. To address this limitation, and amplify plasticity and recovery of breathing following cervical SCI, our ongoing research aims to use novel therapies to promote repair of phrenic motor pathways that control function of the diaphragm – a respiratory muscle essential to breathing.

Dr. Michael Lane's Figure


Locke K, Randelman ML, Hoh DJ, Zholudeva LV, Lane MA
Respiratory plasticity following spinal cord injury: Perspectives from mouse to man.
In press at Neural Regeneration Research
Lyandysha V Zholudeva, Victoria E Abraira, Kajana Satkunendrarajah, Todd C McDevitt, Martyn D Goulding, David S K Magnuson, Michael A Lane
Spinal Interneurons as Gatekeepers to Neuroplasticity after Injury or Disease
J Neurosci. 2021 Feb 3;41(5):845-854. doi: 10.1523/JNEUROSCI.1654-20.2020. Epub 2021 Jan 20.
Itzhak Fischer, Jennifer N Dulin, Michael A Lane
Transplanting neural progenitor cells to restore connectivity after spinal cord injury
Nat Rev Neurosci. 2020 Jul;21(7):366-383. doi: 10.1038/s41583-020-0314-2. Epub 2020 Jun 9.


Tuesday, December 7, 2021 - 12:30pm


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Darlene White

Conditions & Recovery

Spinal Cord Injury icon
Around the world, between 300,000 and 500,000 people are living with a SCI.