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Neural Regeneration Through Reprogramming In Vivo
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Weekly Seminar | Not Open to the PublicHost:
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AbstractÂ
A long term goal of our research is to develop innovative strategies to understand and identify therapeutics for neural injuries and degenerative diseases. Our laboratory pioneered cell fate programming in the adult rodent brain and spinal cord. We showed that reactive glial cells can be in vivo reprogrammed into neural progenitors and functionally mature neurons. Furthermore, the identity of endogenous mature neurons can also be reprogrammed. These results provide new perspectives on cell identity maintenance and potential therapeutics.
Publications
Stem Cell Reports. 2018 Nov 13;11(5):1156-1170. doi: 10.1016/j.stemcr.2018.09.004. Epub 2018 Oct 11.
Cell Rep. 2016 Oct 11;17(3):891-903. doi: 10.1016/j.celrep.2016.09.038.
Nat Cell Biol. 2013 Oct;15(10):1164-75. doi: 10.1038/ncb2843. Epub 2013 Sep 22.