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Molecular Mechanisms Underlying Neural Connectivity

Weekly Seminar
Who Should Attend: 


We are interested in cellular and molecular mechanisms that mediate neural connectivity, some of which are phylogenetically conserved. The mammalian retina provides is a particularly robust system for examining the molecules and cellular mechanisms that organize neuronal cell bodies and their processes in a precise manner to specific laminae. This presentation will include analyses of the cellular and molecular mechanisms that direct starburst amacrine cell (SAC) bodies and neural processes to their normal laminar locations in the retina. Conserved lamination mechanisms in the Drosophila CNS will also be considered, along with our current efforts to extend our work toward an understanding of neocortical lamination in the mouse.

Dr. Kolodkin's Figure


Xie X, Tabuchi M, Brown MP, Mitchell SP, Wu MN, Kolodkin AL
The laminar organization of the Drosophila ellipsoid body is semaphorin-dependent and prevents the formation of ectopic synaptic connections.
Elife. 2017 Jun 20;6. pii: e25328. doi: 10.7554/eLife.25328.
Sun LO, Brady CM, Cahill H, Al-Khindi T, Sakuta H, Dhande OS, Noda M, Huberman AD, Nathans J, Kolodkin AL
Functional assembly of accessory optic system circuitry critical for compensatory eye movements.
Neuron. 2015 May 20;86(4):971-984. doi: 10.1016/j.neuron.2015.03.064. Epub 2015 May 7.
Wang Q, Chiu SL, Koropouli E, Hong I, Mitchell S, Easwaran TP, Hamilton NR, Gustina AS, Zhu Q, Ginty DD, Huganir RL, Kolodkin AL
Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons.
Neuron. 2017 Dec 6;96(5):1084-1098.e7. doi: 10.1016/j.neuron.2017.10.029. Epub 2017 Nov 16.


Tuesday, October 29, 2019 - 12:30pm


785 Mamaroneck Avenue
White Plains, NY 10605
United States
Conference Room: 
Billings Building – Rosedale

More Information

Lindsey Echevarria