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Molecular Characterization of Spinal Motor Circuits

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Gene Expression Laboratory


The spinal cord contains neural circuitry for controlling movement, but the developmental processes and cellular networks that regulate the intricate patterns of muscle activation that underlie motor behaviors are poorly understood. Sam Pfaff is known for characterizing one of the earliest examples of molecular diversification among neuronal subtypes through his analyses of the combinatorial activity of the LIM homeodomain gene family in spinal neurons. In this talk Sam will describe his lab’s recent genetic studies of spinal neurons during development, disease, and repair from injury.


Martins, L.F., Brambilla, I., Motta, A., De Pretis, S., Bhat, G., Badaloni, A., Malpighi, C., Amin, N.D., Imai, F., Almeida, R.D., Yoshida, Y., *Pfaff, S.L., *Bonanomi, D.
Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity
Neuron . 2022 Dec 21;110(24):4090-4107.e11. doi: 10.1016/j.neuron.2022.09.021. Epub 2022 Oct 13.
Osseward PJ II, Amin ND, Moore JD, Temple BA, Barriga BK, Bachmann LC, Beltran F, Gullo M, Clark RC, Driscoll SP, *Pfaff SL, Hayashi M.
Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets
Science . 2021 Apr 23;372(6540):385-393. doi: 10.1126/science.abe0690.
*Amin ND, Senturk G, Costaguta G, Driscoll S, O’Leary B, Bonanomi D, *Pfaff SL.
A hidden threshold in motor neuron gene networks revealed by modulation of miR-218 dose
Neuron . 2021 Oct 20;109(20):3252-3267.e6. doi: 10.1016/j.neuron.2021.07.028. Epub 2021 Aug 26.


Tuesday, February 14, 2023 - 12:30pm


Conference Room: 
Billings Building – Rosedale / Zoom

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Darlene White