You are here

Mitochondrial Dynamics and Ca2+ Transport in the Regulation of Susceptibility to Epilepsy and Stroke

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Dr. Yuriy Usachev's Photo
John P. Long Endowed Professor, Professor of Neuroscience, Pharmacology and Anesthesia


Mitochondria play a central role in cell bioenergetics and control multiple aspects of neuronal life and death. Neurons are particularly dependent on proper mitochondrial function, because of the high energy demands as-sociated with maintenance of ionic gradients and synaptic vesicle recycling. Mitochondria are highly dynamic organelles shaped by fission and fusion, which affects mitochondrial transport, synaptic plasticity and survival. Mitochondria also play a prominent role in Ca2+ signaling and Ca2+-dependent functions in neurons including ex-citability, synaptic plasticity, ATP synthesis, and neurotoxicity. In the first part of his talk, Dr. Usachev will focus on the roles of the mitochondrial Ca2+ uniporters MCU and MCUb in shaping neuronal Ca2+ signaling, regulating synaptic transmission and controlling neural network excitability and susceptibility to seizures and epilepsy. In the second half of his presentation, Dr. Usachev will describe the role of phosphorylation-dependent regulation of mitochondrial fission and fusion (MFF) and the role of protein kinase A/AKAP1 and protein phosphatase PP2A/Bβ2 signaling complexes in regulating mitochondrial dynamics and bioenergetics as well as controlling resistance to neuronal toxicity in ischemic stroke. How the MFF machinery and mitochondrial Ca2+ transport interact and how both processes could be therapeutically targeted for treating stroke and epilepsy will be also discussed.

Dr. Yuriy Usachev's Diagram


Yuliya V Medvedeva, Man-Su Kim, Yuriy M Usachev
Mechanisms of prolonged presynaptic Ca2+ signaling and glutamate release induced by TRPV1 activation in rat sensory neurons
J Neurosci. 2008 May 14;28(20):5295-311. doi: 10.1523/JNEUROSCI.4810-07.2008.
Man-Su Kim, Yuriy M Usachev
Mitochondrial Ca2+ cycling facilitates activation of the transcription factor NFAT in sensory neurons
J Neurosci. 2009 Sep 30;29(39):12101-14. doi: 10.1523/JNEUROSCI.3384-09.2009.
Kyle H Flippo, Zhihong Lin, Audrey S Dickey, Xinchang Zhou, Nirav A Dhanesha, Grant C Walters, Yujia Liu, Ronald A Merrill, Robert Meller, Roger P Simon, Anil K Chauhan, Yuriy M Usachev, Stefan Strack
Deletion of a Neuronal Drp1 Activator Protects against Cerebral Ischemia
J Neurosci. 2020 Apr 8;40(15):3119-3129. doi: 10.1523/JNEUROSCI.1926-19.2020. Epub 2020 Mar 6.
Jacob E Rysted, Zhihong Lin, Grant C Walters, Adam J Rauckhorst, Maria Noterman, Guanghao Liu, Eric B Taylor, Stefan Strack, Yuriy M Usachev
Distinct properties of Ca 2+ efflux from brain, heart and liver mitochondria: The effects of Na +, Li + and the mitochondrial Na +/Ca 2+ exchange inhibitor CGP37157
Cell Calcium. 2021 Jun;96:102382. doi: 10.1016/j.ceca.2021.102382. Epub 2021 Feb 22.


Tuesday, October 12, 2021 - 12:30pm


Conference Room: 
Online Webinar

More Information

Darlene White

Conditions & Recovery

Neurodegenerative Diseases icon
Worldwide, 50 million people are living with Alzheimer's and other dementias.
Stroke icon
Stroke is the leading cause of disability in the U.S.