Mechanisms of Neuronal Injury and Stress Response

Abstract

Using single axon injury assay in C. elegans, we systematically screened the function of >1500 C. elegans genes and identified numerous axon regeneration pathways. Among them, we have elucidated signaling pathways for the DLK-1 MAP kinase. In this talk, I will describe the findings and strategies to understand the context specificity of MAP kinase mediated signal transduction mechanisms.