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Mechanisms of Neuronal Injury and Stress Response
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Abstract
Using single axon injury assay in C. elegans, we systematically screened the function of >1500 C. elegans genes and identified numerous axon regeneration pathways. Among them, we have elucidated signaling pathways for the DLK-1 MAP kinase. In this talk, I will describe the findings and strategies to understand the context specificity of MAP kinase mediated signal transduction mechanisms.
Publications
Neuron . 2011 Sep 22;71(6):1043-57. doi: 10.1016/j.neuron.2011.07.009. Epub 2011 Sep 21.
Elife . 2018 Nov 21;7:e39756. doi: 10.7554/eLife.39756.
Neuron . 2019 Oct 23;104(2):290-304.e8. doi: 10.1016/j.neuron.2019.07.004. Epub 2019 Aug 1.