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Mechanisms of Neuronal Injury and Stress Response

Who Should Attend: 
Event Flyer: 
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Distinguished Professor
Junior Seau Foundation Endowed Faculty Chair


Using single axon injury assay in C. elegans, we systematically screened the function of >1500 C. elegans genes and identified numerous axon regeneration pathways. Among them, we have elucidated signaling pathways for the DLK-1 MAP kinase. In this talk, I will describe the findings and strategies to understand the context specificity of MAP kinase mediated signal transduction mechanisms. 


Lizhen Chen, Zhiping Wang, Anindya Ghosh-Roy, Thomas Hubert, Dong Yan, Sean O'Rourke, Bruce Bowerman, Zilu Wu, Yishi Jin, Andrew D Chisholm
Axon regeneration pathways identified by systematic genetic screening in C. elegans
Neuron . 2011 Sep 22;71(6):1043-57. doi: 10.1016/j.neuron.2011.07.009. Epub 2011 Sep 21.
Kyung Won Kim, Ngang Heok Tang, Christopher A Piggott, Matthew G Andrusiak, Seungmee Park, Ming Zhu, Naina Kurup, Salvatore J Cherra 3rd, Zilu Wu, Andrew D Chisholm, Yishi Jin
Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD+ in axon regeneration
Elife . 2018 Nov 21;7:e39756. doi: 10.7554/eLife.39756.
Matthew G Andrusiak, Panid Sharifnia, Xiaohui Lyu, Zhiping Wang, Andrea M Dickey, Zilu Wu, Andrew D Chisholm, Yishi Jin
Inhibition of Axon Regeneration by Liquid-like TIAR-2 Granules
Neuron . 2019 Oct 23;104(2):290-304.e8. doi: 10.1016/j.neuron.2019.07.004. Epub 2019 Aug 1.


Tuesday, March 28, 2023 - 12:30pm


Conference Room: 
Billings Building – Rosedale
Zoom Meeting

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Darlene White