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Lineage Progression of Cortical Neural Stem Cells and Cortical Excitatory Neuron Cell Fate Specification

Who Should Attend: 
Event Flyer: 
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Developmental Neurobiology
Professor of Molecular, Cell, and Developmental Biology


The production of proper numbers of diverse neurons and macroglia by neural stem cells (NSCs) is essential for neural circuit formation and brain function. During development, neural stem cells (NSCs) in the cerebral cortex, known as the radial glial cells (RGCs), generate glutamatergic neurons that populate different cortical layers. As the generation of excitatory neurons ceases, cortical RGCs switch lineages and generate oligodendrocytes, astrocytes, and GABAergic olfactory bulb (OB) interneurons. Proper control of this lineage switch ensures the production of diverse neuronal and glial cell types in correct numbers. I will discuss our recent progress in understanding the molecular mechanisms underlying the lineage switch of cortical NSCs and cortical excitatory neuron fate specification.


Matthew J Eckler, Ton D Nguyen, William L McKenna, Ben L Fastow, Chao Guo, John L R Rubenstein, Bin Chen
Cux2-positive radial glial cells generate diverse subtypes of neocortical projection neurons and macroglia
Neuron . 2015 May 20;86(4):1100-1108. doi: 10.1016/j.neuron.2015.04.020.
Yue Zhang, Guoping Liu, Teng Guo, Xiaoyi G Liang, Heng Du, Lin Yang, Aparna Bhaduri, Xiaosu Li, Zhejun Xu, Zhuangzhi Zhang, Zhenmeiyu Li, Miao He, Jeremiah Tsyporin, Arnold R Kriegstein, John L Rubenstein, Zhengang Yang, Bin Chen
Cortical Neural Stem Cell Lineage Progression Is Regulated by Extrinsic Signaling Molecule Sonic Hedgehog
Cell Rep . 2020 Mar 31;30(13):4490-4504.e4. doi: 10.1016/j.celrep.2020.03.027.
Jeremiah Tsyporin, David Tastad, Xiaokuang Ma, Antoine Nehme, Thomas Finn, Liora Huebner, Guoping Liu, Daisy Gallardo, Amr Makhamreh, Jacqueline M Roberts, Solomon Katzman, Nenad Sestan, Susan K McConnell, Zhengang Yang, Shenfeng Qiu, Bin Chen
Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons
Cell Rep . 2021 Jun 22;35(12):109269. doi: 10.1016/j.celrep.2021.109269.


Tuesday, April 18, 2023 - 12:30pm


Conference Room: 
Billings Building – Rosedale
Zoom Meeting

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Darlene White