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Investigating Transcranial Direct Current Stimulation in Post-Stroke Motor Recovery: Advance Study from Phase I to Phase II

Weekly Seminar | Not Open to the Public
Who Should Attend: 


Professor of Neurology and Biomedical Engineering Chief
Division of Stroke & Vascular Neurology Director


Transcranial Direct Current Stimulation (tDCS) is a non-invasive format of neuro-modulation tool that can modulate cortical excitability and induce clinical changes in stroke patients with motor impairment. The optimal dose of tDCS is unknown and has been investigated. A meta-analysis suggests there is a dose-response relationship between current density and motor impairment reduction in stroke patients which high dose may leads to better efficacy. It was further proved that high dose correlates with strong electrical field strength in human brain in vivo. A phase I safety and tolerability study demonstrates that it is safe and tolerable to escalate dose/ current to 4mA in stroke patient. A 12-center phase II dose selection clinical trial titled “TRANScranial direct current stimulation for POst-stroke motor Recovery—a phase II sTudy (TRANSPORT2)” is ongoing on the NIH funded stroke trial network. This study aims to investigate the preliminary efficacy and safety and feasibility of tDCS, along with modified constraint-induced movement therapy, in first-ever ischemic stroke patients. Three dose groups will be tested including sham stimulation, low dose (2mA) and high dose (4mA) with 129 subjects. This study also investigates whether assessing the integrity of corticospinal tract by an imaging method (i.e. weighted corticospinal tract lesion load) or a neurophysiology method (i.e. presence of motor evoked potential by transcranial magnetic stimulation) can predict the therapeutic response to tDCS.


Wuwei Feng, Steve Kautz, Mark George, Caitlyn Ellerbe, Gottfried Schlaug, Pratik Chhatbar
Transcranial Direct Current Stimulation for Stroke Motor Recovery: Challenges and Opportunity
PM R . 2018 Sep;10(9 Suppl 2):S157-S164. doi: 10.1016/j.pmrj.2018.04.012.
Pratik Chhatbar, Steve Kautz, Marc George, Hernan Bayona, Shimeng Liu, Wuwei Feng
Safety and tolerability of transcranial direct current stimulation to stroke patients - A phase I current escalation study
Brain Stimul . 2017 May-Jun;10(3):553-559. doi: 10.1016/j.brs.2017.02.007. Epub 2017 Feb 27.
Pratik Y Chhatbar, Steven A Kautz, Istvan Takacs, Nathan C Rowland, Gonzalo J Revuelta, Mark S George, Marom Bikson, Wuwei Feng
Evidence of transcranial direct current stimulation-generated electric fields at subthalamic level in human brain in vivo Affiliations expand
Brain Stimul . 2018 Jul-Aug;11(4):727-733. doi: 10.1016/j.brs.2018.03.006. Epub 2018 Mar 13.


Tuesday, January 24, 2023 - 12:30pm


Conference Room: 
Billings Building – Rosedale

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Darlene White